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EC number: 412-180-1 | CAS number: 10221-57-5 1,2-DIETHOXYPROPANE; DIETHOXY-1,2-PROPANE
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Acute oral toxicity: LD50 (male/female) > 2000 mg/kg bw (equivalent or similar to OECD 401/GLP)
Acute dermal toxicity: LD50 (male/female) > 2000 mg/kg bw (equivalent or similar to OECD 402/GLP)
Key value for chemical safety assessment
Acute toxicity: via oral route
Link to relevant study records
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 16th July 1991 - 2nd December 1991
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- GLP compliance:
- yes
- Test type:
- standard acute method
- Limit test:
- yes
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Charles River (UK) Limited, Manston Road, Margate, Kent
- Females (if applicable) nulliparous and non-pregnant: Yes
- Age at study initiation: 6-8 weeks old
- Weight at study initiation: 171-216 g
- Fasting period before study: Yes; overnight prior to dosing and 3 h post dosing
- Housing: polypropylene cages with mesh floors suspended over absorbent paper lined trays, with a maximum of 5 animals per cage.
- Diet: Rat and Mouse No. 1 Maintenance Diet, supplied by Special Diets Services, 1 Stepfield, Witham, Essex, CM8 3AD ad libitum
- Water: Tap water ad libitum
- Acclimination: 7 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 19-21°C mean relative humidity was 55%.
- Humidity (%): Mean relative humidity was 55%
- Photoperiod (hrs dark / hrs light): A 12 h light/dark cycle was in operation
- Route of administration:
- oral: gavage
- Vehicle:
- other: Tween 80
- Details on oral exposure:
- VEHICLE
- Concentration in vehicle: 200 mg/mL
MAXIMUM DOSE VOLUME APPLIED: 10mL/kg
- Doses:
- 2000 mg/kg bw
- No. of animals per sex per dose:
- 5 males
5 females - Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: Observed frequently on the day of dosing and once daily for 14 days following dosing.
- Frequency of weighing: They were weighed immediately prior to dosing, 7 days after dosing and at sacrifice at the end of the 14 day observation period.
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs - Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Mortality:
- There were no deaths.
- Clinical signs:
- other: Clinical signs were noted 30 mins - 4 hrs after dosing, included piloerection, soiled coat, reduced activity, ataxia and subdued behaviour.
- Gross pathology:
- There were no abnormalities detected at necropsy.
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- In an acute oral toxicity study in Sprague Dawley rats the LD50 (male/female) was >2000 mg/kg bw.
- Executive summary:
In an acute oral toxicity study (8279), groups (5/sex) of Sprague Dawley rats were given a single oral dose of 1,2-Diethoxypropane in Tween-80 by gavage at 2000 mg/kg bw. Animals were then observed for 14 days.
LD50 (male/female): > 2000 mg/kg bw.
Clinical signs were noted 30 mins - 4 hrs after dosing, included piloerection, soiled coat, reduced activity, ataxia and subdued behaviour. There was no mortality and no abnormalities were detected at necropsy. Body weight gains were acceptable.
Reference
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 2 000 mg/kg bw
- Quality of whole database:
- There is one study available and it has a Klimisch score of 2.
Acute toxicity: via inhalation route
Link to relevant study records
- Endpoint:
- acute toxicity: inhalation
- Data waiving:
- study scientifically not necessary / other information available
- Justification for data waiving:
- other:
Reference
Endpoint conclusion
- Endpoint conclusion:
- no study available
Acute toxicity: via dermal route
Link to relevant study records
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 16th July 1991 - 3rd December 1991
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 402 (Acute Dermal Toxicity)
- GLP compliance:
- yes
- Test type:
- standard acute method
- Limit test:
- yes
- Specific details on test material used for the study:
- SOURCE OF TEST MATERIAL
- lot/batch No.of test material: 9059
STABILITY AND STORAGE CONDITIONS OF TEST MATERIAL
- Storage condition of test material: The test material, a colourless liquid, was stored in the dark under ambient conditions. - Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Charles River (UK) Limited, Manston Road, Margate, Kent
- Females (if applicable) nulliparous and non-pregnant: Yes
- Age at study initiation: 6-8 weeks old
- Weight at study initiation: 171-216 g
- Fasting period before study: Yes; overnight prior to dosing and 3 h post dosing
- Housing: polypropylene cages with mesh floors suspended over absorbent paper lined trays, with a maximum of 5 animals per cage.
- Diet: Rat and Mouse No. 1 Maintenance Diet, supplied by Special Diets Services, 1 Stepfield, Witham, Essex, CM8 3AD ad libitum
- Water: Tap water ad libitum
- Acclimination: 7 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 19-21°C mean relative humidity was 55%.
- Humidity (%): Mean relative humidity was 55%
- Photoperiod (hrs dark / hrs light): A 12 h light/dark cycle was in operation - Type of coverage:
- occlusive
- Vehicle:
- unchanged (no vehicle)
- Details on dermal exposure:
- TEST SITE
- Area of exposure: Rats were prepared by clipping the backs free of hair, approximately 24 h before application of the test material. Care was taken to avoid abrading the skin. The test material was applied evenly onto a gauze dressing which was applied to the shaved back of each rat.
- % coverage: 10%
- Type of wrap if used: Strip of non-irritating tape
REMOVAL OF TEST SUBSTANCE
- Washing (if done): The skin wiped with a water dampened tissue to remove excess test material.
- Time after start of exposure: 24 hrs - Duration of exposure:
- 24 hrs
- Doses:
- 2000 mg/kg bw
- No. of animals per sex per dose:
- 5 males
5 females - Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: The rats were observed frequently on the day of dosing and once daily for 14 days following dosing
- Frequency of observations and weighing: They were weighed immediately prior to dosing, 7 days after dosing and at sacrifice at the end of the 14 day observation period.
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs - Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Mortality:
- There were no mortalities.
- Clinical signs:
- other: There were no clinical signs.
- Gross pathology:
- No abnormalities were detected at necropsy.
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- In an acute dermal toxicity study in Sprague-Dawley rats, the LD50 (male/female) was >2000 mg/kg bw.
- Executive summary:
In an acute dermal toxicity study (8279), groups of Sprague-Dawley rats (5/sex) were dermally exposed (10% body surface area; occlusive) to 1,2-Diethoxypropane for 24 hours. The substance was removed after 24 hrs with washing. Animals were then observed for 14 days.
Dermal LD50 (Males/Females) = >2000 mg/kg bw
There was no mortality and no clinical signs were noted. No abnormalities were detected at necropsy. Body weight gains were acceptable.
Reference
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 2 000 mg/kg bw
- Quality of whole database:
- There is one study available and it has a Klimisch score of 2.
Additional information
Acute oral toxicity
There is one oral toxicity study in the rat available.
In an acute oral toxicity study (equivalent or similar to OECD 401/GLP), groups (5/sex) of Sprague Dawley rats were given a single oral dose of 1,2-Diethoxypropane in Tween-80 by gavage at 2000 mg/kg bw. Animals were then observed for 14 days. Clinical signs were noted 30 mins - 4 hrs after dosing, included piloerection, soiled coat, reduced activity, ataxia and subdued behaviour. There was no mortality and no abnormalities were detected at necropsy. Body weight gains were acceptable. The acute oral LD50 (males/females) was >2000 mg/kg bw.
Acute dermal toxicity
There is one dermal toxicity study in the rat available.
In an acute dermal toxicity study (equivalent or similar to OECD 402/GLP), groups of Sprague-Dawley rats (5/sex) were dermally exposed (10% body surface area; occlusive) to 1,2-Diethoxypropane for 24 hours. The substance was removed after 24 hrs with washing. Animals were then observed for 14 days. There was no mortality and no clinical signs were noted. No abnormalities were detected at necropsy. Body weight gains were acceptable. The acute dermal LD50 (males/females) was >2000 mg/kg bw.
These studies are acceptale to use in the human health risk assessment.
Justification for classification or non-classification
Based on the available information in the dossier, the substance 1,2-Diethoxypropane (CAS No. 10221-57-5) does not need to be classified for acute toxicity or specific target organ toxicity - single exposure, when the criteria outlined in Annex I of 1272/2008/EC are applied.
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