Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 203-183-7 | CAS number: 104-19-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Six ecotoxicological studies performed with the test substance are available. The acute toxicity study of rainbow trout (Envigo, 2018) resulted in an 96 hour LC50 > 29 mg/L (based on nominal concentrations). Based on this result it can be concluded that the test substance is not harmful to fish. Two relevant studies were identified and were used in a weight of evidence approach to assess acute toxicity to aquatic invertebrates in Daphnia magna according to OECD guideline 202. Based on nominal concentrations, the study of Migchielsen (2002) revelated a 48-h EC50 of 39 mg/L. An EC50 of 66 mg/L (based on nominal test concentrations) was found after an exposure of 48 hours in a static test in freshwater (Squance, 2018). The study of Migchielsen (2002) was considered for the PNEC derivation. Based on the results it can be concluded that the test substance is harmful to aquatic invertebrates. Two relevant studies were identified as key studies and were used in a weight of evidence approach to assess toxicity of the test substance to aquatic algae according to OECD guideline 201. Migchielsen (2002) obtained a nominal EC50 for growth rate inhibition (72-h ErC50) of 36 mg/L with a 95% confidence interval ranging from 30 to 43 mg/L. In the study of Envigo (2018), the 72-h NOEC and 72-h EC50 for growth rate were determined to be 3.2 mg/L and 29 mg/L respectively. The latter study was considered for the PNEC derivation. The substance can be considered as harmful to algae.
The study of Best (2017), investigating the toxicity of the test substance to microorganisms according to OECD guideline 209, was considered as the key study for endpoint coverage. The 3-h EC50 was >1000 mg/L. The 3-h NOEC was 1000 mg/L.
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.