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EC number: 948-040-6
CAS number: -
mean viabilities for each treatment group
Percentage Viability (% SD / % CoV)*
100 (0.068 / 6.0)
6.2 (0.078 / 20.6)
89.1 (0.090 / 8.8)
100 (0.061 / 4.9)
-1.4 (0.034 / 23.2)
52.0 (0.022 / 3.4)
of 2 replicates
controls set to 100 %
431 (2017) - The skin corrosivity potential of Reaction Mass of
N,N,N’,N’-tetrabutylmethylenediamine and dibutylamine was assessed using
an EpiDerm Reconstructed Human Epidermis (RHE) Model Kit in accordance
with OECD guidance 431 and GLP.
tissues were treated with the test item for exposure periods of 3 and 60
mins. At the end of the exposure period the test item was rinsed from
each tissue before being loaded with MTT. After MTT loading each tissue
was placed in 2 mL isopropanol for MTT extraction. After extraction,
each tissue was pierced and the extraction solution aliquoted for
absorbance measurements. Absorbency at 570 nm of each well was measured
using a spectrophotometer.
test item was considered to be non-corrsive to the skin under the
conditions of the test.
viability of tissues exposed to the test substance after 3 and 60
minutes were 89.1 and 52.0 %, respectively. The quality criteria
required for acceptance of the results was met.
the conditions of this study the test substance is not considered to be
corrosive to the skin.
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