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EC number: 948-040-6
CAS number: -
of animals dead (and with evident toxicity)
(# dead / total)
Time range of deaths
Number with evident toxicity
(# / total)
3 / 6
2 / 6
0 / 6
OECD 423 (2017) - This study was conducted to assess the acute toxicity
of the test article (Reaction Mass of
N,N,N',N-tetrabutylmethylenediamine and dibutylamine), following a
single oral administration to small groups of rats. The study design
provides information for hazard assessment and classification and
enables a chemical to be assigned to toxicity classes but severely
restricts animal usage.
300 mg/kg and 2000 mg/kg. Treatment of animals was sequential.
Sufficient time was allowed between each group to confirm the survival
of the previously dosed animals.
The test article was used undiluted for the 300 and 2000 mg/kg dose
levels and was dispersed in corn oil for the 50 mg/kg dose level.
Surviving animals were killed on Day 15. All animals underwent a full
Two animals treated at 2000 mg/kg were found dead on Day 2. One other
animal was humanely killed due to the severity of the clinical signs on
There were no deaths at dose levels of 50 or 300 mg/kg.
Decreased activity and hunched posture were noted 3 and 4 hours after
dosing, in one animal treated at 2000 mg/kg. Hypothermia, ptosis,
piloerection, laboured breathing and prone posture were noted in the
animal that was killed in extremis. No clinical signs were seen prior to
death in the two animals that were found dead.
No clinical signs were seen in animals treated at 50 or 300 mg/kg.
All surviving rats achieved body weight gains during the first and
second weeks of the study.
No abnormalities were noted at necropsy of animals that died or were
killed in extremis during the study or at necropsy of those that were
killed at the end of the study.
Based of the experimental conditions of this study, the test article was
classified as Category 4 in respect of its acute oral toxicity according
to the Globally Harmonized System of Classification and Labelling of
Chemicals (GHS). Based on the observed effects the LD50 using the
cut-off value was estimated to be 500 mg/kg bw.
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