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Key value for chemical safety assessment

Effects on fertility

Description of key information

It is worth noting that although the treatment level was set at 200 mg/l in drinking water, a dose of 50 mg/l over 90 days in a sub-chronic study results in biochemical changes with higher protein levels. These parameters were not examined in this study, but even over a shorter exposure period, it is likely that some blood chemistry changes will have occured.

These numbers were higher in females that had been exposed, but mated with non-exposed males, than in non-exposed females where males were exposed, suggesting maternal exposure is the predominant concern.

Note that based on nominal animal weights and typical water consumption, the treatment leval was ca 50 mg/kg/day of vanadyl oxysulphate

Effect on fertility: via oral route
Endpoint conclusion:
adverse effect observed
Dose descriptor:
LOAEL
50 mg/kg bw/day
Study duration:
subchronic
Species:
rat

Effects on developmental toxicity

Effect on developmental toxicity: via oral route
Endpoint conclusion:
adverse effect observed
Dose descriptor:
LOAEL
50 mg/kg bw/day
Study duration:
subchronic
Species:
rat

Justification for classification or non-classification