Registration Dossier

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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Ecotoxicological information

Endpoint summary

Administrative data

Description of key information

Short-term toxicity to aquatic invertebrates

The short-term toxicity of Thio Isocyanate Adduct to the freshwater aquatic invertebrate, Daphnia magna, was assessed via an OECD Guideline 202 (‘Daphnia sp. Acute Immobilisation Test’) study. The study was performed at a GLP accredited laboratory, fulfilled the validity criteria described by the guideline and is well documented and is therefore considered to be reliable.  

                                                                                                                  

Exposures of D. magna to the test item showed that the 48 hour EC50 was beyond the considered maximum soluble concentration of the test item (i.e.exceeded an average exposure concentration of 0.0062 mg/L for the first constituent and of 5.1 mg/L for the second constituent).

Toxicity to aquatic algae and cyanobacteria

The toxicity of Thio Isocyanate Adduct to the freshwater algae, Pseudokirchneriella subcapitata, was assessed via an OECD Guideline 201 (‘Freshwater Alga and Cyanobacteria, Growth Inhibition Test’) study. The study was performed at a GLP accredited laboratory, fulfilled the validity criteria described by the guideline and is well documented and is therefore considered to be reliable.  

Exposures of P. subcapitata to the test item resulted in Time Weighted Average (TWA) measured 72 hour EL50 values of >100 mg/L for both growth rate inhibition and yield. The 72 hour EC50 based on the first constituent was >0.20 µg/L for both growth rate inhibition and yield. The 72 hour EC50 based on the second constituent was 59 µg/L for both growth rate inhibition and yield. The resulting 72 hour NOELR values for growth rate inhibition and yield were 32 mg/L based on statistical significance and 100 mg/L based on biological relevance. The resulting 72 hour NOEC values based on the first constituent for growth rate inhibition and yield was 0.054 µg/L based on statistical significance and 0.20 µg/L based on biological relevance. The resulting 72 hour NOEC values based on the first constituent for growth rate inhibition and yield was 11 µg/L based on statistical significance and 59 µg/L based on biological relevance.

Additional information