Registration Dossier

Administrative data

Endpoint:
vapour pressure
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
other: non-GLP guideline study, but test procedure well documented

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2012
Report Date:
2012

Materials and methods

Test guidelineopen allclose all
Qualifier:
according to
Guideline:
OECD Guideline 104 (Vapour Pressure Curve)
Deviations:
yes
Remarks:
see 'Principles of method if other than guideline'
Qualifier:
according to
Guideline:
EU Method A.4 (Vapour Pressure)
Deviations:
yes
Remarks:
see 'Principles of method if other than guideline'
Principles of method if other than guideline:
The vapour pressure of the test substance itself was considered to low as to be determinable with the effusion method. As the melting point of the test substance was determined with 235 to 242 °C (508.2 to 515.2 K) under decomposition, the result is plausible and a calculated value is applicable. Therefore, also calculation was performed using the modified Grain-Watson Method with the software EPISUITE Vers. 4.1 by the Environmental Protection Agency (US EPA).
GLP compliance:
no
Type of method:
effusion method: by loss of weight or by trapping vaporisate

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
- Name of test material (as cited in study report): (1R)-1-[(4R,4aR,8aS)-2,6-bis(4-chlorophenyl)tetrahydro[1,3]dioxino[5,4-d][1,3]dioxin-4-yl]ethane-1,2-diol
- Expiration date of the lot/batch: December 2012
- Storage condition of test material: Room Temperature: (20 ± 5°C); Keep away from humidity

Results and discussion

Vapour pressureopen allclose all
Temp.:
20 °C
Vapour pressure:
0 Pa
Remarks on result:
other: Vapour pressure for the minor impurities of the test substance calculated from the regression equation
Temp.:
25 °C
Vapour pressure:
0 Pa
Remarks on result:
other: Vapour pressure for the minor impurities of the test substance calculated from the regression equation
Temp.:
25 °C
Vapour pressure:
0 Pa
Remarks on result:
other: Vapour pressure for the test substance calculated with EPIWIN

Applicant's summary and conclusion

Conclusions:
The vapour pressure of the test substance is, considering the vapour pressure values of the minor components, < 4.02E-06 Pa at 20°C and < 6.66E-06 Pa at 25°C.