Registration Dossier

Administrative data

Endpoint:
partition coefficient
Type of information:
experimental study
Adequacy of study:
key study
Study period:
29 Aug - 13 Sep 2018
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2018

Materials and methods

Test guideline
Qualifier:
according to
Guideline:
OECD Guideline 107 (Partition Coefficient (n-octanol / water), Shake Flask Method)
GLP compliance:
yes (incl. certificate)
Type of method:
flask method
Partition coefficient type:
octanol-water

Test material

Reference
Name:
Unnamed
Type:
Constituent
Test material form:
liquid

Study design

Analytical method:
high-performance liquid chromatography
mass spectrometry

Results and discussion

Partition coefficientopen allclose all
Key result
Type:
log Pow
Partition coefficient:
-1.6
Temp.:
20 °C
pH:
7
Key result
Type:
log Pow
Partition coefficient:
0.1
Temp.:
20 °C
pH:
11

Applicant's summary and conclusion

Conclusions:
The shake flask method at pH 7 and pH 11 was applied for the determination of the partition coefficient (Pow) of t-Butyldiethanolamine.
pH 7: The Pow value of the test item was 2.5 x 10-2 corresponding to a log Pow value of -1.6.
pH 11: The Pow value of the test item was 1.4 x 100 corresponding to a log Pow value of 0.1.
Executive summary:

Information

Guideline(s)

Result

Comment

Partition coefficient

EC A.8
OECD 107
OPPTS 830.7550

log Powfor pH 7: -1.6

log Powfor pH 11:0.1

at 20°C by the shake flask method