Registration Dossier

Administrative data

Endpoint:
hydrolysis
Data waiving:
study scientifically not necessary / other information available
Justification for data waiving:
other:
Justification for type of information:
The 3 cited publications are on 2-aminoethanol, not 2-aminoethanol hydrobromide.
A read-across approach was indeed performed between 2-aminoethanol hydrobromide (target substance) and 2-aminoethanol (source substance).
QSAR predictions for salt substances such as 2-aminoethanol hydrobromide used to remove the counter ion (or the inorganic part, or the lowest MW part of the salt molecule) and, if necessary, the subsequent neutralization. This procedure is needed to calculate the descriptors used to make the predictions. This read-across approach has been confirmed by several experts, both academic and regulators (European Agency for chemicals, ECHA).

Data source

Referenceopen allclose all

Reference Type:
publication
Title:
Environmental fate constantsfor organic chemicals under consideration for EPA's hazardous waste identification projects
Author:
Kollig, HP et al.
Year:
1993
Bibliographic source:
EPA/600/R-93/132
Reference Type:
review article or handbook
Title:
Handbook of property estimation methods for chemicals
Author:
Boethling, R., MacKay, D.
Year:
2000
Bibliographic source:
CRC Press, Boca Raton, FL, USA
Reference Type:
publication
Title:
Rate of hydrolysis
Author:
Harris JC
Year:
1990
Bibliographic source:
in: Lyman WJ et al., Handbook of chemical property estimation methods, 3rd edition, ACS Washington.

Materials and methods

Test material

Reference
Name:
Unnamed
Type:
Constituent

Results and discussion

Applicant's summary and conclusion