Registration Dossier
Registration Dossier
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EC number: 282-500-0 | CAS number: 84238-45-9
Endpoint summary
Administrative data
Key value for chemical safety assessment
Genetic toxicity in vitro
Description of key information
No genetic toxicity study with Benzenesulfonic acid, 4-dodecyl-, cerium(4+) salt, basic is available, thus the genetic toxicity will be addressed with existing data on the individual assessment entities cerium andbenzenesulfonic acid, 4-C10-13-sec-alkyl derivs.
Benzenesulfonic acid, 4-dodecyl-, cerium(4+) salt, basic is not expected to be mutagenic in bacteria, since the two moieties cerium andbenzenesulfonic acid, 4-C10-13-sec-alkyl derivshave not shown gene mutation potential in bacteria.
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (negative)
Additional information
Cerium
The genotoxic potential was assessed by performing an in vitro gene mutation study in bacteria. S. typhimurium TA 1535, TA 1537, TA98 and TA 100 as well as E.coli WP2 uvr A were used for the main study. Different concentrations of cerium chloride were analysed with and without metabolic activation in all strains. The test item, cerium chloride, was considered to be non-mutagenic with and without metabolic activation, under the conditions of this test.
benzenesulfonic acid, 4-C10-13-sec-alkyl derivs
4-undecylbenzenesulfonate was negative in the bacterial Ames test with S. typhimurium strains TA 98, TA 100, TA 1535, TA 1537 and TA1538 with and without metabolic activation (Schoeberl, 1993).
Benzenesulfonic acid, 4-dodecyl-, cerium(4+) salt, basic
Benzenesulfonic acid, 4-dodecyl-, cerium(4+) salt, basic is not expected to be mutagenic in bacteria, since the two moieties cerium andbenzenesulfonic acid, 4-C10-13-sec-alkyl derivshave not shown gene mutation potential in bacteria. Further testing is not required. For further information on the toxicity of the individual moieties, please refer to the relevant section in the IUCLID.
Justification for classification or non-classification
Benzenesulfonic acid, 4-dodecyl-, cerium(4+) salt, basic is not expected to be genotoxic, since the two moieties cerium andbenzenesulfonic acid, 4-C10-13-sec-alkyl derivshave not shown gene mutation potential in bacteria. Due to the lack of data, specifically for in vitro clastogenicity in mammalian cells, no decision can be made with regard to classification as germ cell mutagen.
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