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Ecotoxicological information

Short-term toxicity to fish

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Administrative data

Link to relevant study record(s)

Reference
Endpoint:
short-term toxicity to fish
Type of information:
experimental study
Adequacy of study:
key study
Study period:
07 Feb 18 - 17 April 2018
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Qualifier:
according to guideline
Guideline:
OECD Guideline 203 (Fish, Acute Toxicity Test)
Deviations:
no
GLP compliance:
yes
Specific details on test material used for the study:
Reference Identification: STB-FR; sodium 2,4,5-trichlorobenzenesulphonate
CAS#: 53423-65-7
EC#: 258-548-3
Label Identification: Arichem, LLC; 187 Sloss Industries Road; Ariton, AL 36311 USA
Product Sample: Sodium Trichlorobenzene Sulfonate
Lot: 1708-09; Approx 100g
Date & Quantity Received: 29 Jan 18; 109.7 g (GW)
Physical Description: White powder
Storage Conditions: Room temperature
Purity: 100% active ingredient, refer to the Sponsor provided Certificate of Analysis
Analytical monitoring:
no
Remarks:
Substance is a non-volatile solid and known to be stable in water at environmetal pH
Vehicle:
no
Test organisms (species):
Pimephales promelas
Details on test organisms:
Justification of Species: One of the species specified in the regulatory guidelines
Source: STILLMEADOW, Inc.
Age: Range-finding: Juvenile (DOB: 14-16 Jan 18); Limit Test: Juvenile (DOB: 24-26 Jan 18)
Size: Range-finding: 0.0731-0.1317 g (mean: 0.1048 g) and 1.7-2.2 mm (mean: 2.0 mm)
Size: Limit Test: 0.0731-0.1163 g (mean: 0.0962 g) and 1.7-1.9 mm (mean: 1.8 mm)
Quantity: Range-finding: 10 organisms per test concentration and control Limit: 3 replicates of 10 organisms for test concentration and control
Test type:
static
Water media type:
freshwater
Limit test:
yes
Total exposure duration:
96 h
Hardness:
85 mg/L CaCO3
Test temperature:
Target: 23 ± 2°C
Actual: 21-22°C
pH:
Range finding: 7.4
Limit Test: 7.6
Dissolved oxygen:
Range-finding: 72-97%
Limit Test: 84-98%
Conductivity:
357.1 - 371.4 µmhos/cm
Nominal and measured concentrations:
Range-finding: 0.1, 1, 10, 50 and 100 mg/L
Limit Test: 100 mg/L
Reference substance (positive control):
no
Key result
Duration:
96 h
Dose descriptor:
LC50
Effect conc.:
> 100 mg/L
Nominal / measured:
nominal
Conc. based on:
test mat.
Basis for effect:
mortality (fish)
Details on results:
No mortalities were observed at the limit dose concentration of 100 mg/L.
Sublethal observations / clinical signs:

Table 1: Limit Test Mortality Results

Conc.

(mg/L)

Replicate

Number of Surviving Organisms

Mortality

0 Hrs

6 Hrs

24 Hrs

48 Hrs

72 Hrs

96 Hrs

Control

A

10

10

10

10

10

10

0.00%

B

10

10

10

10

10

10

C

10

10

10

10

10

10

100

A

10

10

10

10

10

10

0.00%

B

10

10

10

10

10

10

C

10

10

10

10

10

10

Note: All organisms has not observable abnormalities unless otherwise indicated

Conc. - Concentration; Hrs - Hours

Validity criteria fulfilled:
yes
Conclusions:
The LC50 was determined to be >100 mg/L
Executive summary:

In a GLP guidline study conducted according to OECD 203, the substance was evaluated for toxicity to Pimephales promelas in a 96-hour static nonrenewal test at a limit dose of 100 mg/L. All fish survived the study and, thus, the LC50 was determined to be >100 mg/L. There was no observable abnormalities in any of the test groups during any point of the study.

Description of key information

In a GLP guidline study conducted according to OECD 203, the substance was evaluated for toxicity toPimephales promelasin a 96-hour static nonrenewal test at a limit dose of 100 mg/L. All fish survived the study and, thus, the LC50 was determined to be >100 mg/L. There was no observable abnormalities in any of the test groups during any point of the study.

Key value for chemical safety assessment

Additional information

The LC50 was determined to be >100 mg/L