Registration Dossier
Registration Dossier
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EC number: 274-288-3 | CAS number: 70049-77-3
Particle size distribution (Granulometry)
Administrative data
- Endpoint:
- particle size distribution (granulometry)
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 017
- Report date:
- 2017
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: Technical Guidance Document EUR 20268 Determination of Particle Size Distribution
- Version / remarks:
- The method employed was based on a procedure designed to be compatible with that given in European Commission Technical Guidance Document EUR 20268 Determination of Particle Size Distribution, Fibre Length and Diameter Distribution of Chemical Substances (2002).
- Deviations:
- no
- Principles of method if other than guideline:
- The particle size distribution was evaluated based on internationally accepted guidelines. The inhalable fraction is defined as the mass fraction of particles which can be inhaled by nose or mouth, the thoracic fraction is defined as the mass fraction of particles that passes the larynx and the respirable fraction is defined as the mass fraction of particles that reaches the alveoli.
- GLP compliance:
- yes
- Type of method:
- determination of fibre length and diameter distributions
- Type of particle tested:
- other: powder
- Type of distribution:
- mass based distribution
Test material
- Reference substance name:
- 3-(aminosulphonyl)-4-chlorobenzoyl chloride
- EC Number:
- 274-288-3
- EC Name:
- 3-(aminosulphonyl)-4-chlorobenzoyl chloride
- Cas Number:
- 70049-77-3
- Molecular formula:
- C7H5Cl2NO3S
- IUPAC Name:
- 4-chloro-3-sulfamoylbenzoyl chloride
- Test material form:
- solid: particulate/powder
Constituent 1
Results and discussion
- Mass median aerodynamic diameter:
- < 100 µm
Particle size distribution at different passages
- No.:
- #1
- Size:
- < 100 µm
- Distribution:
- ca. 7.7 %
- Remarks on result:
- other: The inhalable percentage identified was insufficient to allow further characterisation of the thoracic fraction and respirable fraction by the cascade impactor method.
Applicant's summary and conclusion
- Conclusions:
- The proportion of test item having an inhalable particle size of less than 100 μm was determined by a sieve method to be 7.7%. The inhalable percentage identified was insufficient to allow further characterisation of the thoracic fraction and respirable fraction by the cascade impactor method.
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