Registration Dossier
Registration Dossier
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EC number: 942-725-3 | CAS number: -
Endpoint summary
Administrative data
Link to relevant study record(s)
Description of key information
Category members share (i) eye damage and (ii) the absence of significant systemic toxicity.
Key value for chemical safety assessment
Additional information
Similar toxicokinetics
The Category members are expected to be absorbed to a lower extent via the skin and via inhalation and to a more significant extent via the gastrointestinal tract. In repeated dose oral toxicity study performed with sodium cocoyl apple amino acids salt (category member), the observed clinical, clinicochemical and (histo)pathological effects demonstrate bioavailability from the gastrointestinal tract with respect to the control group. However, there was no indication of a cumulative toxicity in this study.
It has been shown that the greatest skin penetration of the human epidermis was with C10 and C12 soaps and the rate of percutaneous absorption of sodium laurate is greater than that of most other anionic surfactants. (Prottey and Ferguson, 1975; Madsen et al., 2001; Howes, 1975).
Howes (1975) studied the percutaneous absorption of some anionic surfactants and showed that sodium decanoate was reportedly poorly absorbed through the skin of rats when in uncovered contact for 15 minutes. Penetration through excised human skin proceeded at a rate similar to that for excised rat skin for up to 6 hours; thereafter absorption through human skin was slightly quicker. Also, for the three soaps which penetrated the skin (C10, C12 and C14) there was a lag time of 1 hour before any measurable penetration occurred, but after this the rate of penetration steadily increased. Howes also calculated from human epidermal studies in vitro that only small amounts of the C10, C12 and C14 soaps would be likely to penetrate the skin from a 15 minute wash and rinse in vivo. The low penetration rates of the C16 and C18 soaps suggests that little or none of these would penetrate from a 15 minute wash and rinse in vivo.
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