Registration Dossier
Registration Dossier
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EC number: 807-113-1 | CAS number: 3709-71-5
Skin sensitisation
Administrative data
- Endpoint:
- skin sensitisation: in vivo (LLNA)
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 1 (reliable without restriction)
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 007
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 429 (Skin Sensitisation: Local Lymph Node Assay)
- GLP compliance:
- yes
- Type of study:
- mouse local lymph node assay (LLNA)
Test material
- Reference substance name:
- (E)-1,1,1,2,3,4,5,5,5-Nonafluoro-4-(trifluoromethyl)pent-2-ene
- Cas Number:
- 3709-71-5
- Molecular formula:
- C6F12
- IUPAC Name:
- (E)-1,1,1,2,3,4,5,5,5-Nonafluoro-4-(trifluoromethyl)pent-2-ene
- Test material form:
- liquid
Constituent 1
In vivo test system
Test animals
- Species:
- mouse
- Strain:
- CBA/Ca
- Sex:
- female
Study design: in vivo (LLNA)
- Vehicle:
- unchanged (no vehicle)
- Concentration:
- Undiluted
- No. of animals per dose:
- 4
- Positive control substance(s):
- hexyl cinnamic aldehyde (CAS No 101-86-0)
Results and discussion
- Positive control results:
- The control was considered to be a sensitiser under the conditions of the test.
In vivo (LLNA)
Results
- Key result
- Parameter:
- SI
- Value:
- ca. 0.28
- Test group / Remarks:
- Value for blank was 0.52
- Cellular proliferation data / Observations:
- Zero clinical observations and mortailities.
Any other information on results incl. tables
Note that this was done at a single concentration; I assume because even at 100% there was no effect.
Applicant's summary and conclusion
- Conclusions:
- "The test material was considered to be a non-sensitiser under the conditions of the test.
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