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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Physical & Chemical properties

Dissociation constant

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Administrative data

Link to relevant study record(s)

Reference
Endpoint:
dissociation constant
Type of information:
experimental study
Adequacy of study:
key study
Study period:
19 December 2016 - 07 July 2017
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Qualifier:
according to guideline
Guideline:
OECD Guideline 112 (Dissociation Constants in Water)
Deviations:
no
Qualifier:
according to guideline
Guideline:
EPA OPPTS 830.7370 (Dissociation constants in water)
Deviations:
no
GLP compliance:
yes (incl. QA statement)
Specific details on test material used for the study:
- Batch nĀ°: M16FB2273
- Analytical purity: 101.7% (w/w)
- Expiration date: 12 September 2017
- Storage condition: at room temperature
Dissociating properties:
no
Remarks:
The test item does not contain ionisable groups. No pKa values could be calculated.

The test item does not contain ionisable groups. No pKavalues could be calculated.

Conclusions:
JNJ-42808389-AAA (T003421) has no pKa values for acidic and basic groups in the logarithm range of 1 ā€“ 14.

Description of key information

The calculation method was applied in a GLP study (K1, Ciric, 2017) as a preliminary test to determine the dissociation constant. Since the test item does not contain ionisable groups, no pKa could be calculated.

Key value for chemical safety assessment

Additional information