Registration Dossier
Registration Dossier
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EC number: 202-809-6 | CAS number: 100-00-5
Toxicity to reproduction: other studies
Administrative data
- Endpoint:
- toxicity to reproduction: other studies
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: GLP - guideline study
Data source
Referenceopen allclose all
- Title:
- No information
- Author:
- Chou BJ, Leach CL, Miller RA, Horstman MG, Ragan HA, Bucher|JR, Roycroft JH (1991) 13-week subchronic inhalation|toxicity of 4-chloronitrobenzene (4-DCB) in rodents. The|Toxicologist 11: 87 Abstr. 262
- Title:
- No information
- Author:
- NTP (1993) 2-Chloronitrobenene and 4-Chloronitrobenzene:|Administered by inhalation to F344/N rats and B6C3F1 mice.|Toxicity Report Series No. 33, NIH Publication, 93-3382,|July/1993
Materials and methods
- Principles of method if other than guideline:
- Type: other: subchronic
Method: other: 10 rats/sex/group of the 0,6, 12, 24 ppm groups, whole body exposure, f: necropsy bw, estrous cycle length, percent of cycle spent in the various stages; m: necropy bw, reproduct. tissue weights, spermatozoal data, spermatogenes - GLP compliance:
- yes
- Type of method:
- in vivo
Test material
- Reference substance name:
- 1-chloro-4-nitrobenzene
- EC Number:
- 202-809-6
- EC Name:
- 1-chloro-4-nitrobenzene
- Cas Number:
- 100-00-5
- Molecular formula:
- C6H4ClNO2
- IUPAC Name:
- 1-chloro-4-nitrobenzene
- Details on test material:
- - Name of test material (as cited in study report): 1-chloro-4-nitrobenzene
- Analytical purity: 98.8 %
Constituent 1
Test animals
- Species:
- rat
- Strain:
- other: F344/N
- Sex:
- male/female
Administration / exposure
- Route of administration:
- inhalation
- Duration of treatment / exposure:
- 13 w
- Frequency of treatment:
- 6 h/d, 5 d/w
Doses / concentrations
- Remarks:
- Doses / Concentrations:
0, 1.5, 3, 6, 12, or 24 ppm (= ca. 0.0, 9.81, 19.62, 39.24, 78.48,or 156.96 mg/m³ air)
Basis:
- Control animals:
- yes, concurrent vehicle
- Details on study design:
- Duration of test: 13 w
Results and discussion
Observed effects
Any other information on results incl. tables
6, 12 and 24 ppm: among females, average estrous cycle
length significantly decreased
24 ppm: among males, left caudal epididymal and
testicular weights, epididymal sperm (spermatozoa) count per
gram of caudal tissue and total spermatid head count per
testis significantly decreased
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
