Registration Dossier
Registration Dossier
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EC number: 202-809-6 | CAS number: 100-00-5
Repeated dose toxicity: other routes
Administrative data
- Endpoint:
- repeated dose toxicity: other route
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Study period:
- 1972
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: migrated IUCLID4 data set
Data source
Reference
- Reference Type:
- publication
- Title:
- No information
- Author:
- Labunskii VV (1972) Die Wirkung aromatischer Nitro-, Chlor- und Aminoverbindungen auf das Herz-Kreislaufsystem im Experiment. Farmakol Toksikol 7: 156-159
Materials and methods
- GLP compliance:
- no
Test material
- Reference substance name:
- 1-chloro-4-nitrobenzene
- EC Number:
- 202-809-6
- EC Name:
- 1-chloro-4-nitrobenzene
- Cas Number:
- 100-00-5
- Molecular formula:
- C6H4ClNO2
- IUPAC Name:
- 1-chloro-4-nitrobenzene
- Details on test material:
- - Name of test material (as cited in study report): 1-chloro-4-nitrobenzene
- Analytical purity: no data
Constituent 1
Test animals
- Species:
- rat
- Strain:
- not specified
- Sex:
- not specified
Administration / exposure
- Route of administration:
- subcutaneous
- Duration of treatment / exposure:
- 10 d
- Frequency of treatment:
- daily
Doses / concentrations
- Remarks:
- Doses / Concentrations:
100 mg/kg bw/d
- Control animals:
- yes
- Details on study design:
- Post-exposure period: no
Results and discussion
Target system / organ toxicity
- Critical effects observed:
- not specified
Any other information on results incl. tables
methaemoglobinaemia, anaemia, marked loss of body
weight, lowering of the blood pressure, decrease in
the rhythm of cardiac contractions, increase in the
weight coefficient of the heart
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
