Registration Dossier

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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Description of key information

Skin irritation: Non irritating to skin in vitro (Episkin method)
Eye irritation: Not corrosive to eyes or a severe irritant to eyes in vitro (BCOP); Not a mild nor a moderate irritant to rabbits eye based on read across to structural analogue, Cyclohexyl salicylate

Key value for chemical safety assessment

Skin irritation / corrosion

Endpoint conclusion
Endpoint conclusion:
no adverse effect observed (not irritating)

Eye irritation

Endpoint conclusion
Endpoint conclusion:
no adverse effect observed (not irritating)

Respiratory irritation

Endpoint conclusion
Endpoint conclusion:
no study available

Additional information

To address toxicological endpoints as part of the REACH registration of the REACH registration of Amyl Salicylate (Target Substance) it is proposed to read-across to Cyclohexyl Salicylate (Source Substance).

The use of read-across works within the spirit of REACH and the stated aim of the legislation to reduce animal testing where possible.

The Target Substance and Source Substance have been characterised using the categories and databases present in the OECD [Q]SAR Toolbox. From the profiling, it can be seen that the two substances share structural similarities and also ‘mechanistic action’ similarities which are both general and endpoint specific.

For classification purposes this demonstrates that read across is valid and Amyl salicylate is not classified in accordance with CLP based on the Source substance, Cyclohexyl salicylate also not being classified.

Justification for classification or non-classification

The test substance was assessed for skin and eye irritation. There was no potential for skin irritation (Episkin method)

within the framework of Regulation (EC) No. 1272/2008 (CLP) or in accordance with Regulation 67/548/EEC.

Furthermore, the substance is not corrosive to eyes or a severe irritant to eyes in vitro (BCOP); Not a mild nor a moderate irritant to rabbits eye based on read across to structural analogue, Cyclohexyl salicylate and classification in accordance with Regulation (EC) No. 1272/2008 (CLP) or in accordance with Regulation 67/548/EEC is not required.