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Diss Factsheets

Administrative data

Endpoint:
adsorption / desorption: screening
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
other: Well documented guideline study without deviation

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2002
Report date:
2002

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
OECD Guideline 106 (Adsorption - Desorption Using a Batch Equilibrium Method)
Deviations:
no
GLP compliance:
yes (incl. QA statement)
Type of method:
batch equilibrium method
Media:
soil

Test material

Constituent 1
Reference substance name:
(2-carboxyethyl)({2-[(2-carboxyethyl)(2-hydroxyethyl)amino]ethyl})azanium; [({2-[(2-carboxyethyl)(2-hydroxyethyl)amino]ethyl}carbamoyl)methyl](dodecyl)dimethylazanium; ethanol
IUPAC Name:
(2-carboxyethyl)({2-[(2-carboxyethyl)(2-hydroxyethyl)amino]ethyl})azanium; [({2-[(2-carboxyethyl)(2-hydroxyethyl)amino]ethyl}carbamoyl)methyl](dodecyl)dimethylazanium; ethanol
Radiolabelling:
no

Study design

Test temperature:
20 °C (+/-) 2 °C

Batch equilibrium or other method

Analytical monitoring:
yes
Details on sampling:
- Concentrations: 21 mg/l
- Sampling times adsorption (hours): 3:45, 6:15, 23:45, 47
-Sampling time desorption: 4:30 h
Duration of adsorption equilibrationopen allclose all
Sample No.:
#1
Duration:
47 h
Initial conc. measured:
21.621 other: µg/mL
pH:
5.06
Temp.:
20 °C
Sample No.:
#2
Duration:
47 h
Initial conc. measured:
21.212 other: µg/mL
pH:
7.1
Temp.:
20 °C
Sample No.:
#3
Duration:
47 h
Initial conc. measured:
21.11 other: µg/mL
pH:
7.13
Temp.:
20 °C
Sample No.:
#4
Duration:
47 h
Initial conc. measured:
21.459 other: µg/mL
pH:
5.18
Temp.:
20 °C
Sample No.:
#5
Duration:
47 h
Initial conc. measured:
21.107 other: µg/mL
pH:
7.63
Temp.:
20 °C
Duration of desorption equilibrationopen allclose all
Sample no.:
#1
Duration:
4 h
Conc. of adsorbed test mat.:
0.148 other: µg/mL
pH:
4.9
Temp.:
20 °C
Sample no.:
#2
Duration:
4 h
Conc. of adsorbed test mat.:
0.304 other: µg/mL
pH:
6.94
Temp.:
20 °C
Sample no.:
#3
Duration:
4 h
Conc. of adsorbed test mat.:
0.269 other: µg/mL
pH:
6.37
Temp.:
20 °C
Sample no.:
#4
Duration:
4 h
Conc. of adsorbed test mat.:
0.299 other: µg/mL
pH:
5.06
Temp.:
20 °C
Sample no.:
#5
Duration:
4 h
Conc. of adsorbed test mat.:
0.228 other: µg/mL
pH:
6.94
Temp.:
20 °C

Results and discussion

Adsorption coefficientopen allclose all
Type:
Koc
Value:
7 353
Temp.:
20 °C
Remarks on result:
other: Soil: Speyer 2.1
Type:
Koc
Value:
2 454
Temp.:
20 °C
Remarks on result:
other: Soil: Cranfield 115
Type:
Koc
Value:
1 370
Temp.:
20
Remarks on result:
other: Soil: Cranfield 164
Type:
Koc
Value:
3 755
Temp.:
20 °C
Remarks on result:
other: Soil: Cranfield 243
Type:
Koc
Value:
1 778
Temp.:
20 °C
Remarks on result:
other: Soil: Speyer 6 S
Type:
Kd
Value:
41.4
Temp.:
20 °C
Remarks on result:
other: Soil: Speyer 2.1
Type:
Kd
Value:
41.3
Temp.:
20 °C
Remarks on result:
other: Soil: Cranfield 115
Type:
Kd
Value:
41.3
Temp.:
20 °C
Remarks on result:
other: Soil: Cranfield 164
Type:
Kd
Value:
41.4
Temp.:
20 °C
Remarks on result:
other: Soil: Cranfield 243
Type:
Kd
Value:
41.3
Temp.:
20 °C
Remarks on result:
other: Soil: Speyer 6 S
Partition coefficientsopen allclose all
Phase system:
other: Kom (organic matter normalised adsorption coefficient)
Type:
other: Kom (organic matter normalised adsorption coefficient)
Value:
4 265 L/kg
Remarks on result:
other: Soil: Speyer 2.1
Phase system:
other: organic matter normalised adsorption coefficient
Type:
other: organic matter normalised adsorption coefficient
Value:
1 423 L/kg
Remarks on result:
other: Soil: Cranfield 115
Phase system:
other: organic matter normalised adsorption coefficient
Type:
other: organic matter normalised adsorption coefficient
Value:
795 L/kg
Remarks on result:
other: Soil: Cranfield 164
Phase system:
other: organic matter normalised adsorption coefficient
Type:
other: organic matter normalised adsorption coefficient
Value:
2 178 L/kg
Remarks on result:
other: Soil: Cranfield 243
Phase system:
other: organic matter normalised adsorption coefficient
Type:
other: organic matter normalised adsorption coefficient
Value:
1 031 L/kg
Remarks on result:
other: Soil: Speyer S 6

Results: Batch equilibrium or other method

Transformation products:
no
Details on results (Batch equilibrium method):
MAIN TEST: PERFORMANCE
- Test material stability during adsorption/desorption phase: substance is stable
- Experimental conditions maintained throughout the study: Yes

Any other information on results incl. tables

Measured test substance concentrations in adsorption/desorption samples were all <= 1 mg/L for Speyer 2.1 soil and all < 1 mg/L for the other four soils. This would correspond to at least 95.3 % adsorption of test substance on all test soils. However, in view of the fact that high (> 90 %) and low (< 10%) degrees of adsorption cannot be accurately determined for unlabelled test substances and in view of the results for the calibration curves, these results were deemed uncertain. Notwithstanding, from the analyses it became clear that the adsorption/desorption samples all contained <= 1 mg test substance/L. The concentration of 1 mg test substance/L, corresponding to 95 % adsorption in all test soils, was therefore taken as the maximum value for the test substance concentration in all samples and used in the calculations of Kd, KOC, K, and Kdes. The results for the adsorption and desorption coefficients are therefore to be regarded as minimum values.

Applicant's summary and conclusion

Validity criteria fulfilled:
yes
Executive summary:

The adsorption behaviour of the substance on five soils, encompassing a range of pH values, soil types (i.e. % clay, silt and sand) and % organic matter was investigated according to OECD guideline 106. The test soils were Speyer 2.1 [0.97% organic matter (OM), sand], Speyer 6 S [4.0 % OM, clay], Cranfield 115 [2.9 % OM, clay loam], Cranfield 164 [5.2 % OM, silt loam] and Cranfield 243 [1.9% OM, sandy loam]. Adsorption was studied using the batch equilibrium method. Adsorption and desorption kinetics were determined at an initial test substance concentration of approximately 21 mg/L and at 20 °C (+/-) 2 °C in the dark. Adsorption equilibrium was reached very quickly within 4 hours. There was no indication that the substance adsorbed to the container walls or was unstable during the adsorption test. The analytical method available for the substance had to be modified for measurement of adsorption/desorption samples, but nevertheless remained unsatisfactory for accurately quantifying the substance in these samples. For the calculation of the adsorption coefficients, a maximum equilibrium concentration of test substance of 1 mg/L could be taken. Mean Kom ads (organic matter normalised adsorption coefficient) values were 4265 cm3/g (Speyer 2.1) 1423 cm3/g (Cranfield 115), 795 cm3/g (Cranfield 164), 2178 cm3/g (Cranfield 243) and 1031 cm3/g (Speyer 6 S). The substance can therefore be considered to be immobile in all five soils investigated according to the classification scheme by Mensink.