Reaction products of 2-hydroxyethyl methacrylate and diphosphorous pentoxide and water

Boiling point

Link to relevant study record(s)

Reference

Reference 1

Endpoint:

boiling point

Type of information:

experimental study

Adequacy of study:

key study

Study period:

20-02-2018 to 26-07-2018

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Remarks:

Guideline study performed under GLP. All relevant validity criteria were met.

Qualifier:

according to guideline

Guideline:

OECD Guideline 103 (Boiling Point)

Deviations:

no

Qualifier:

according to guideline

Guideline:

EU Method A.2 (Boiling Temperature)

Deviations:

no

Qualifier:

according to guideline

Guideline:

EPA OPPTS 830.7220 (Boiling Point / Boiling Range)

Deviations:

no

GLP compliance:

yes

Type of method:

differential scanning calorimetry

Boiling pt.:

> 75 °C

Atm. press.:

1 atm

Decomposition:

yes

Decomp. temp.:

> 75 °C

Remarks on result:

other: Boiling of the test substance was not observed below the temperature at which reaction and/or decomposition started.

Preliminary study

The TGA curve of the test item was determined starting at 225°C, the weight of the sample decreased significantly. At 244°C, the sample weight had decreased by 25%.

 

Main study

- Experiment 1: An exothermic effect was observed between 75°C and 100°C. The exothermic effect was probably obtained due to reaction and/or decomposition of the test item.

- Experiment 2: A duplicate DSC was performed to further investigate the glass transition of the test item. Similar results as in Experiment 1 were obtained. The inflection point of the glass transition peak was -53.791°C. After the experiment it was observed that the test item was unchanged. As difference in the inflection point between Experiment 1 and Experiment 2 was > 0.5°C, Experiment 3 was performed.

- Experiment 3: Using conditions similar to Experiment 2, the inflection point of the glass transition was -53.442°C. Since result of the Experiment 3 was in line with the inflection points observed in Experiment 1 and Experiment 2, results were accepted.

Conclusions:

Reaction and/or decomposition of the test item were observed ≥ 75°C (≥ 348 K). Boiling of the test item was not observed below 75°C. The test item boiling point is > 75°C at 1 atmosphere pressure.

Executive summary:

The boiling temperature was examined using OECD TG 103 and EU Method A.2. and the Differential Scanning Calorimetry method under GLP. Reaction and/or decomposition of the test item was observed during DSC experiments at temperatures ≥ 75°C (or ≥ 348 K) at 1 atmosphere pressure under a stream of nitrogen. Boiling of the test item was not observed below the temperature at which reaction and/or decomposition started. The boiling temperature of the substance has been determined to be > 75°C at 1 atmosphere pressure.

Reference 2

Endpoint:

boiling point

Data waiving:

study technically not feasible

Justification for data waiving:

other:

Justification for type of information:

JUSTIFICATION FOR DATA WAIVING
A study has been conducted to OECD TG 103 and EU Method A.2 – DSC method indicating that the substance boils above a decomposition temperature of 75°C under inert gas conditions. Further testing at reduced pressures is omitted on the following basis:
1. Adequate information is already available: i. on the substances physical state (liquid up to 75°C); ii. for Classification and Labelling Purposes and where reliable data is provided: on Flash Point (≥ 124°C), Auto-ignition temperature (335°C, 1 atm) and Vapour Pressure (≤ 12 Pa at 25°C).
2. In accordance with REACH Regulation (EC) No. 1907/2006 Annex VII, column 2 section 7.3 the study does not need to be conducted since the substance decomposes before boiling (e.g. autoxidation, rearrangement, degradation, decomposition etc).
3. In accordance with section 2 of REACH Regulation (EC) No. 1907/2006 Annex XI, further testing is omitted on the basis that the substance undergoes autoxidation/rearrangement at temperatures > 75 °C; with due regard OECD TG 103, paragraph 4 which states that the methods in the guideline are applicable to liquids provided they do not undergo chemical changes below the boiling point. Additional testing to derive a boiling point is not technically feasible; in that testing at reduced pressure would yield information only on boiling points of degradation products (not of the substance). Additional testing would not yield relevant further information for classification and labelling purposes.

References:
1. ECHA Guidance on Information Requirements and Chemical Safety Assessment (Chapter R.7a: Endpoint Specific Guidance, R.7.1.10.2, v6.0, July 2017)
2. REACH Regulation (EC) 1907/2006, Annex XI, section 2
3. CLP Regulation (EC) 1272/2008, Annex I, section 2.6.1
4. ECHA Guidance on Application on the CLP Criteria, (v5.0, July 2016)
5. OECD TG 103 (July 1995)

Description of key information

Bp: decomposition occurs ≥ 75 °C at 1 atm pressure, the boiling point > 75 °C at 1 atm pressure, OECD TG 103, 2018

Additional information

Key study : OECD TG 103, 2018 : The boiling temperature was examined using OECD TG 103 and EU Method A.2. and the Differential Scanning Calorimetry method under GLP. Reaction and/or decomposition of the test item was observed during DSC experiments at temperatures ≥ 75°C (or ≥ 348 K) at 1 atmosphere pressure under a stream of nitrogen. Boiling of the test item was not observed below the temperature at which reaction and/or decomposition started. The boiling temperature of the substance has been determined to be > 75°C at 1 atmosphere pressure.

A study has been conducted to OECD TG 103 and EU Method A.2 – DSC method indicating that the substance boils above a decomposition temperature of 75°C under inert gas conditions. Further testing at reducedpressures is omitted on the following basis:

1. Adequate information is already available: i. on the substances physical state (liquid up to 75°C); ii. for Classification and Labelling Purposes and where reliable data is provided: on Flash Point (≥ 124°C), Auto-ignition temperature (335°C, 1 atm) and Vapour Pressure (≤ 12 Pa at 25°C).

2. In accordance with REACH Regulation (EC) No. 1907/2006 Annex VII, column 2 section 7.3 the study does not need to be conducted since the substance decomposes before boiling (e.g. autoxidation, rearrangement, degradation, decomposition etc).

3. In accordance with section 2 of REACH Regulation (EC) No. 1907/2006 Annex XI, further testing is omitted on the basis that the substance undergoes autoxidation/rearrangement at temperatures > 75 °C; with due regard OECD TG 103, paragraph 4 which states that the methods in the guideline are applicable to liquids provided they do not undergo chemical changes below the boiling point. Additional testing to derive a boiling point is not technically feasible; in that testing at reduced pressure would yield information only on boiling points of degradation products (not of the substance). Additional testing would not yield relevant further information for classification and labelling purposes.

 

References:

1. ECHA Guidance on Information Requirements and Chemical Safety Assessment (Chapter R.7a: Endpoint Specific Guidance, R.7.1.10.2, v6.0, July 2017)

2. REACH Regulation (EC) 1907/2006, Annex XI, section 2

3. CLP Regulation (EC) 1272/2008, Annex I, section 2.6.1

4. ECHA Guidance on Application on the CLP Criteria, (v5.0, July 2016)

5. OECD TG 103 (July 1995)