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Solubility in organic solvents / fat solubility

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Reference
Endpoint:
solubility in organic solvents / fat solubility
Type of information:
experimental study
Adequacy of study:
key study
Study period:
2nd November, 2016
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Qualifier:
according to
Guideline:
other: OECD TG 105
Deviations:
yes
Remarks:
n-octanol used instead of water
GLP compliance:
no
Other quality assurance:
ISO/IEC 17025 (General requirements for the competence of testing and calibration laboratories)
Specific details on test material used for the study:
Batch # 7705878
Medium:
n-octanol
Solubility:
> 2 000 g/L
Temp.:
20 °C
Test substance stable:
not determined
Details on results:
For raw data see Table 1

Table 1: Results of solubility test

 Experiment  n-octanol (g)  Weighed sample (g)  Result
 A 1.64 0.3106  clear liquid
 B  1.64  1.4844  clear liquid
 C  1.64  3.9938  clear liquid

With 3.99 g of test item being mixed into 1.64 g of n-octanol, a clear liquid with a total weight of 5.63 g has been formed. This is equivalent to 70.8 %w/w of test item in solution or a concentration of 2.0 kg/L.

Conclusions:
The n-octanol solubility of the test item is > 2.0 kg/L, or rather unlimited.
Executive summary:

The solubility of the test item in n-octanol was determined using OECD TG 105 (shake flask method). Increasing amounts of the test item were added to 1.64 g of n-octanol at room temperature and the mixtures shaken and allowed to stand for 24 hours. The mixture was visually checked for any undissolved parts of the sample. The solubilty of the test item at 20 °C was determined to be equivalent to 70.8 %w/w, or a concentration of > 2 kg/L (i.e. unlimited solubility).

Description of key information

The test item is infinitely miscible with n-octanol.

Key value for chemical safety assessment

Solubility in organic solvents at 20°C:
2 000 g/L

Additional information

The solubility of the test item in n-octanol was determined using OECD TG 105 (shake flask method). Increasing amounts of the test item were added to 1.64 g of n-octanol at room temperature and the mixtures shaken and allowed to stand for 24 hours. The mixture was visually checked for any undissolved parts of the sample. The solubilty of the test item at 20°Cwas determined to be equivalent to 70.8 %w/w, or a concentration of > 2 kg/L (i.e. unlimited solubility).