Registration Dossier

Administrative data

Endpoint:
boiling point
Type of information:
experimental study
Adequacy of study:
key study
Study period:
13-19 December 2001
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2002
Report Date:
2002

Materials and methods

Test guidelineopen allclose all
Qualifier:
according to
Guideline:
OECD Guideline 103 (Boiling point/boiling range)
Deviations:
no
Qualifier:
according to
Guideline:
EU Method A.2 (Boiling Temperature)
Deviations:
no
GLP compliance:
yes (incl. certificate)
Type of method:
differential scanning calorimetry
Remarks:
differential scanning calorimetry

Test material

Reference
Name:
Unnamed
Type:
Constituent
Test material form:
solid: particulate/powder
Details on test material:
- Name of test material (as cited in study report): JNJ-16169374-AAC (T002113)
- Physical state: solid (powder)
- Appearance: off-white powder
Specific details on test material used for the study:
- Batch n°: RT002113G3A231
- Analytical purity: 92.9%
- Expiration date: 08 April 2002
- Storage condition: at room temperature

Results and discussion

Boiling point
Key result
Atm. press.:
1 013.25 hPa
Decomposition:
yes
Decomp. temp.:
240 °C
Remarks on result:
other: The exothermic reaction was caused by the decomposition of the test item. After the experiment the test item was black and carbonized.

Any other information on results incl. tables

Using thermal analysis, no endothermic peaks were detected in the temperature range between 25 and 400°C from which boiling could be deduced. During the preliminary test, starting at about 240°C, an exothermic reaction was observed. The exothermic reaction was caused by decomposition of the test item. After the experiment the test item was black and carbonized.

Applicant's summary and conclusion

Conclusions:
Decomposition of T002113 was observed before boiling occurred. In conclusion, no boiling point was observed during this test.