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Toxicological information

Skin sensitisation

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Administrative data

Endpoint:
skin sensitisation
Remarks:
in vivo
Type of information:
experimental study
Adequacy of study:
supporting study
Reliability:
2 (reliable with restrictions)

Data source

Reference
Reference Type:
publication
Title:
Unexpected anaphylaxis to cashew nut
Author:
O. Quercia*, S. Rafanelli, L. Marsigli, F. G. Foschi, G. F. Stefanini
Year:
1999
Bibliographic source:
Allergy 54,892-902

Materials and methods

Principles of method if other than guideline:
Allergy to the cashew nut in human case report.
GLP compliance:
not specified
Type of study:
other: anaphylaxis to cashew nut

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
- Name of test material (as cited in study report):Cashew nut

In vivo test system

Test animals

Species:
human
Sex:
male
Details on test animals and environmental conditions:
Not available

Study design: in vivo (non-LLNA)

Inductionopen allclose all
Route:
other: not applicable
Vehicle:
no data
Concentration / amount:
Not available
Challengeopen allclose all
Route:
other: not applicable
Vehicle:
no data
Concentration / amount:
Not available
No. of animals per dose:
Not applicable

Results and discussion

Any other information on results incl. tables

A patient allergic to pistachio who had anaphylaxis due to cashew nuts. A 42- year-old white man was admitted to our emergency room complaining of mouth and lip itching, slurred voice, dyspnea, and vomiting a few minutes after eating some cashew nuts. Prompt treatment with steroids, antihistamines, and epinephrine relieved the patient's symptoms, leading to a complete recovery in about 24 h.

Three years later, the patient complained of the same symptoms while eating pasta with a sauce based on garlic, basil, and pine nuts and attributed the symptoms to pine nuts and basil. After a few months, mouth itching and vomiting occurred again when the patient ate pistachio nuts.

To diagnose an adverse reaction to Anacardiaceae, a skin prick by prick test was performed with a positive result for pistachio and cashew nut.

Applicant's summary and conclusion

Interpretation of results:
sensitising
Remarks:
Migrated informationCriteria used for interpretation of results: EU
Conclusions:
Based on the allergic reactions developed by human due to intake of pistacio and cashew nuts (cashew nut shell liquid being the extract of cashew nut)belonging to the family Anacardiaceae it is concluded that cashew nut shell liquid is a skin sensitiser.
Executive summary:

As illustrated in the case report a patient allergic to pistachio who had anaphylaxis due to cashew nuts reported mouth and lip itching, slurred voice, dyspnea, and vomiting.Three years later, the patient complained of the same symptoms while eating similar products belonging to the family Anacardiaceae. Based on the allergic reactions developed by human due to intake of pistacio and cashew nuts (cashew nut shell liquid being the extract of cashew nut)belonging to the family Anacardiaceae it is concluded that cashew nut shell liquid is a skin sensitiser.