Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 224-756-8 | CAS number: 4477-28-5
Endpoint summary
Administrative data
Description of key information
Non skin sensitizer.
Key value for chemical safety assessment
Skin sensitisation
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not sensitising)
- Additional information:
4-anilinobenzenediazonium hydrogen sulphate was tested in "Lusens test" on the basis to the protocol “LuSens Assay” provided by BASF SE and the OECD Guideline 442D. This test investigates the Key Event 2 (i.e. Keratinocyte response) in the skin sensitisation pathway. In all tested concentrations of the test item for both experiments no substantial and reproducible dose dependent increase of luciferase induction above 1.5 was measured. In conclusion 4-anilinobenzenediazonium hydrogen sulphate is not considered as a potential sensitizer. Combining the result of LuSens test with consideration on physico-chemical properties of the test item, QSAR predictions, information from similar substances and human data available , it is possible to conclude that is not skin sensitiser.
Respiratory sensitisation
Endpoint conclusion
- Endpoint conclusion:
- no study available
Justification for classification or non-classification
According to the CLP Regulation (EC n.1272/2008), Skin sensitiser means a substance that will lead to an allergic response following skin contact. The skin sensitisation potential was investigated according to EU Regulation 2016/1688 - updated regarding skin sensitisation requirement of annex VII of the REACH regulation (EC n. 1907/2006) in force since 11th October 2016. The biological mechanisms of skin sensitisation is a stepwise mechanism (Adverse Outcome Pathway -AOP) that follows these key events: (a) molecular interaction with skin proteins; (b) inflammatory response in keratinocytes; (c) activation of dendritic cells. LuSens test investigates Keratinocyte response. The result of LuSens test on 4-anilinobenzenediazonium hydrogen sulphate was negative. Combining the result of LuSens Test with consideration on physico-chemical properties of the test item, QSAR predictions, information from similar substances and human data available, it is possible to conclude that 4-anilinobenzenediazonium hydrogen sulphate is not skin sensitiser according to the CLP Regulation (EC. n.1272/2008).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
