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Administrative data

Endpoint:
chronic toxicity: inhalation
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
1 (reliable without restriction)

Data source

Reference
Reference Type:
publication
Title:
Hygiene of labour
Author:
Zaugliikov S. D., Predtechenskiy M. B
Year:
1967
Bibliographic source:
Not specified

Materials and methods

Test guideline
Qualifier:
no guideline available
Principles of method if other than guideline:
No information about the principles of method followed.
GLP compliance:
not specified

Test material

Constituent 1
Chemical structure
Reference substance name:
Isopropyl nitrate
EC Number:
216-983-6
EC Name:
Isopropyl nitrate
Cas Number:
1712-64-7
Molecular formula:
C3H7NO3
IUPAC Name:
propan-2-yl nitrate
Test material form:
liquid

Test animals

Species:
rat
Strain:
not specified
Sex:
not specified

Administration / exposure

Route of administration:
inhalation
Type of inhalation exposure:
not specified
Duration of treatment / exposure:
2 hours per day for 4 months
Frequency of treatment:
daily
Doses / concentrations
Dose / conc.:
0.25 mg/L air
Remarks:
The dose varies from 0.2 to 0.3 mg/L.
Control animals:
not specified

Results and discussion

Results of examinations

Clinical signs:
effects observed, treatment-related
Description (incidence and severity):
Low blood pressure
Mortality:
not specified
Body weight and weight changes:
not specified
Food consumption and compound intake (if feeding study):
not examined
Food efficiency:
not examined
Water consumption and compound intake (if drinking water study):
not specified
Ophthalmological findings:
not specified
Haematological findings:
effects observed, treatment-related
Description (incidence and severity):
Blood presure and haemoglobine reduced.
Clinical biochemistry findings:
not specified
Urinalysis findings:
not specified
Behaviour (functional findings):
not specified
Immunological findings:
not specified
Organ weight findings including organ / body weight ratios:
not specified
Gross pathological findings:
not specified
Neuropathological findings:
effects observed, treatment-related
Description (incidence and severity):
Deviations in the fuctioning of the central nervous system.
Histopathological findings: non-neoplastic:
not specified
Histopathological findings: neoplastic:
not specified
Other effects:
not specified

Effect levels

Dose descriptor:
NOAEL
Remarks on result:
not measured/tested

Target system / organ toxicity

Critical effects observed:
not specified
System:
central nervous system

Applicant's summary and conclusion

Conclusions:
Threshold limit value (TLV) for the Isopropyl Nitrate is 5 mg/m3.

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