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EC number: 216-983-6 | CAS number: 1712-64-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Hydrolysis
Administrative data
- Endpoint:
- hydrolysis
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
Data source
Referenceopen allclose all
- Reference Type:
- publication
- Title:
- Hydrolitic decomposition os esters of nitric acids
- Author:
- John W. Baker, D. M. Easty
- Year:
- 1 952
- Bibliographic source:
- Journal of Chemical Society
- Reference Type:
- publication
- Title:
- The chemistry of nitrate esters
- Author:
- R Boschan, R. T. Merrow, P. W. Van Dolah
- Year:
- 1 955
- Bibliographic source:
- ACS Publication
- Reference Type:
- publication
- Title:
- TKinetics, products, reaction mechanisms, and atmospheric impact - Scientific Figure on ResearchGate.
- Author:
- Unknown
- Year:
- 2 016
- Bibliographic source:
- https://www.researchgate.net/The-hydrolysis-rate-constants-s-1-for-isopropyl-nitrate-IPN-red-and-isobutyl_fig1_311624333 [accessed 9 May, 2018]
Materials and methods
Test guideline
- Qualifier:
- no guideline available
- Principles of method if other than guideline:
- Kinetic study of alkaline hydrolysis of isopropyl nitrate in aqueus alcohol.
- GLP compliance:
- no
Test material
- Reference substance name:
- Isopropyl nitrate
- EC Number:
- 216-983-6
- EC Name:
- Isopropyl nitrate
- Cas Number:
- 1712-64-7
- Molecular formula:
- C3H7NO3
- IUPAC Name:
- propan-2-yl nitrate
- Test material form:
- liquid
Constituent 1
Results and discussion
- Transformation products:
- not specified
Dissipation DT50 of parent compound
- pH:
- 6.9
- Hydrolysis rate constant:
- ca. 0 s-1
- Type:
- not specified
- Remarks on result:
- other: No information about the temperature.
- Details on results:
- In all experiments, the addition of an organic nitrate standard to aqueous solution resulted in hydrolysis of the organic nitrate functionality, with first order loss rates that increased
with solution acidity. For the tertiary APN, hydrolysis rate constants ranged from 3.2 ×10−5s−1at neutral pH (6.9) to 2.0 ×10−3s−1at low pH (0.25). The hydrolysis rate constants for the secondary isopropyl nitrate and the primary isobutyl nitrate displayed nearly identical kinetics, and had rate constants smaller by more than 2 orders of magnitude relative to the APN, ranging from 1.23 ×10−7s−1at neutral pH (6.9) to 1.1 ×10−5s−1at low pH (0.25), when
data from both experiments were averaged together.
The average hydrolysis lifetimes of isopropyl nitrate and isobutyl nitrate range from approximately 1 day at low pH to greater than 8 months at neutral conditions.
Applicant's summary and conclusion
- Validity criteria fulfilled:
- not specified
- Conclusions:
- The hydrolysis of organic nitrates within the particle phase will lead to a decreased effective lifetime for
NOx and, thus, decreased ozone transport. However, the observed organic hydrolysis product, pinol, is relatively volatile
and may partition back to the gas phase, decreasing organic aerosol mass.
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