Registration Dossier
Registration Dossier
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EC number: 216-322-1 | CAS number: 1559-34-8
Endpoint summary
Administrative data
Description of key information
Skin irritancy: not irritating
Eye irritancy: severe eye irritant
Key value for chemical safety assessment
Skin irritation / corrosion
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Eye irritation
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (irritating)
Respiratory irritation
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
Skin irritancy
In an old, well reported skin irritation study that followed the basic principles of the current OECD guideline, 2 white Vienna rabbits were treated for 20 hours to the substance 3,6,9,12-tetraoxahexadecan-1-ol under occlusive conditions. No adverse skin reaction was seen.
Eye irritancy
In a guideline GLP eye irritation study, the substance 3,6,9,12-tetraoxahexadecan-1-ol was tested in rabbit eyes to assess the level of eye irritancy produced. Under the conditions of the test, moderate eye irritation was observed, the most acute response being moderate to severe conjunctival erythema and mild to cornal opacity. All symptoms disappeared within 14 days.
In an in vitro assay designed to assess the irritation potential for severe eye damage, 3,6,9,12-tetraoxahexadecan-1-ol was testsed in the HET-CAM = (Hen Egg Test - Chorioallantoic Membrane) assay. The level of response seen was not indicative of a severe eye irritant.
Justification for classification or non-classification
Based on the information available, skin irritancy does not appear to be a significant characteristic of this substance and therefore labelling is not required.
In a guideline eye irritation study, all symptoms disappeared within 14 days. However, the corneal response and the amount of redness produced over the first threee days did meet the criteria for classification under the GHS as a severe eye irritant (Cat 2A).
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