Registration Dossier
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EC number: 216-322-1 | CAS number: 1559-34-8
Short-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
Description of key information
Toxicity to daphnia magna of:
reaction mass of 3,6,9,12-tetraoxahexadecan-1-ol and 2-(2-(2-butoxyethoxy)ethoxy)ethanol: EC50>3200 (48hr) mg/L.
2-(2-(2-butoxyethoxy)ethoxy)ethanol: EC50 (48hr) >500, 2201mg/L.
2-(2-butoxyethoxy)ethanol: EC50 (24hr) 2850, 3200mg/L.
QSAR prediction of toxicity to daphnia magna of triethylene glycol butyl ether: 4800mg/L (48hr LC50)
QSAR prediction of toxicity to daphnia magna of tetraethylene glycol butyl ether: ~10000mg/L (48hr LC50)
Key value for chemical safety assessment
Fresh water invertebrates
Fresh water invertebrates
- Effect concentration:
- 3 200 mg/L
Additional information
The QSAR predicts that the toxicity to daphnia decreases with the increasing molecular weight within the series of ethylene glycol butyl ethers. The toxicity of tetraethylene glycol butyl ether is predicted to be significantly less than that of triethylene glycol which provides support to the use of data from the latter, or mixtures of the tri and tetra, as conservative alternative to data on the pure tetra. The key figure chosen is from a guideline test on a substance tthat was a mixture of tri and tetraethylene glycol butyl ether and is considered representative of the toxicity of pure tetraethylene glycol butyl ether.
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