Registration Dossier
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EC number: 201-335-7 | CAS number: 81-23-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Water solubility
Administrative data
- Endpoint:
- water solubility
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2018
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 018
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 105 (Water Solubility)
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.6 (Water Solubility)
- Qualifier:
- according to guideline
- Guideline:
- other: CIPAC MT 157
- GLP compliance:
- yes
- Type of method:
- column elution method
Test material
- Reference substance name:
- Dehydrocholic acid
- EC Number:
- 201-335-7
- EC Name:
- Dehydrocholic acid
- Cas Number:
- 81-23-2
- Molecular formula:
- C24H34O5
- IUPAC Name:
- (4R)-4-[(1R,3aS,3bR,5aS,9aS,9bS,11aR)-9a,11a-dimethyl-4,7,11-trioxo-hexadecahydro-1H-cyclopenta[a]phenanthren-1-yl]pentanoic acid
- Test material form:
- solid: crystalline
Constituent 1
- Specific details on test material used for the study:
- Batch number: 2016110462
Results and discussion
Water solubility
- Water solubility:
- 0.07 g/L
- Conc. based on:
- test mat.
- Temp.:
- 20 °C
- pH:
- 5.4
Any other information on results incl. tables
Results
Data in the tables are rounded values taken from Excel spreadsheets which will be archived together with the raw data. The use of Excel spreadsheets for calculations produces more accurate endpoints. These endpoints may slightly differ from the values derived by replacing the rounded values in the formulae are given in the methods section.
For all the sample solutions the pH value was 5.4, measured by pH meter.
The quality criteria of the A.6 method were verified (RSD% over three values is < 15%).
Table7 Water Solubility: analytical results
Internal code | As | Cs (1) (mg/mL) | Ds | WaterSolubility (g/L) |
WS A | 110158 | 68.96 | 1 | 0.070 |
WS B | 112784 | 70.63 | 1 | 0.071 |
WS C | 114915 | 71.97 | 1 | 0.072 |
Mean value : | 0.07 | |||
Standard deviation (S.D.) : | 0.002 | |||
Relative Standard Deviation (RSD%) : | 2.14% |
(1) Quantification with the linear calibration curve.
Applicant's summary and conclusion
- Conclusions:
- Water solubility of the substance is 0.07 g/L
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