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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Eye irritation

Currently viewing:

Administrative data

Endpoint:
eye irritation: in vivo
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2003

Materials and methods

Test guideline
Qualifier:
equivalent or similar to guideline
Guideline:
OECD Guideline 405 (Acute Eye Irritation / Corrosion)
GLP compliance:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
Bornan-2-one
EC Number:
200-945-0
EC Name:
Bornan-2-one
Cas Number:
76-22-2
Molecular formula:
C10H16O
IUPAC Name:
1,7,7-trimethylbicyclo[2.2.1]heptan-2-one
Test material form:
solid: crystalline

Test animals / tissue source

Species:
rabbit
Strain:
not specified

Test system

Vehicle:
unchanged (no vehicle)
Amount / concentration applied:
0.1g
Duration of treatment / exposure:
1min
Observation period (in vivo):
7d
Number of animals or in vitro replicates:
4

Results and discussion

In vivo

Resultsopen allclose all
Irritation parameter:
cornea opacity score
Basis:
other: 4 animals
Time point:
other: 4h,24h, 48h, 72h, 4d, 7d
Score:
1
Max. score:
1
Irritation parameter:
iris score
Basis:
other: 4 animals
Time point:
other: 4h,24h, 48h, 72h, 4d, 7d
Score:
0
Max. score:
0
Irritation parameter:
conjunctivae score
Basis:
animal #1
Time point:
other: 4h,24h, 48h, 72h, 4d, 7d
Score:
0.667
Max. score:
2
Irritation parameter:
conjunctivae score
Basis:
animal #2
Time point:
other: 4h,24h, 48h, 72h, 4d, 7d
Score:
0.667
Max. score:
2
Irritation parameter:
conjunctivae score
Basis:
animal #3
Time point:
other: 4h,24h, 48h, 72h, 4d, 7d
Score:
0.333
Max. score:
1
Irritation parameter:
conjunctivae score
Basis:
animal #4
Time point:
other: 4h,24h, 48h, 72h, 4d, 7d
Score:
0.333
Max. score:
1
Irritation parameter:
other: secretion
Basis:
other: 4 animals
Time point:
other: 4h,24h, 48h, 72h, 4d, 7d
Score:
0
Max. score:
0
Irritation parameter:
chemosis score
Basis:
animal #1
Time point:
other: 1h, 24h, 48h, 72h, 4d, 7d
Score:
0.167
Max. score:
1
Irritation parameter:
chemosis score
Basis:
animal #2
Time point:
other: 1h, 24h, 48h, 72h, 4d, 7d
Score:
0.333
Max. score:
1
Irritation parameter:
chemosis score
Basis:
animal #3
Time point:
other: 1h, 24h, 48h, 72h, 4d, 7d
Score:
0.333
Max. score:
1
Irritation parameter:
chemosis score
Basis:
animal #4
Time point:
other: 1h, 24h, 48h, 72h, 4d, 7d
Score:
0.333
Max. score:
1

Applicant's summary and conclusion

Interpretation of results:
not irritating
Remarks:
Migrated information