Registration Dossier
Registration Dossier
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EC number: 239-370-5 | CAS number: 15337-18-5
Partition coefficient
Administrative data
Link to relevant study record(s)
- Endpoint:
- partition coefficient
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 26 July 2016 to 23 April 2018
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.8 (Partition Coefficient - HPLC Method)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 117 (Partition Coefficient (n-octanol / water), HPLC Method)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EPA OPPTS 830.7570 (Partition Coefficient, n-octanol / H2O, Estimation by Liquid Chromatography)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- HPLC method
- Partition coefficient type:
- octanol-water
- Specific details on test material used for the study:
- - Purity: 96.6%
- Description: yellow viscous liquid - Analytical method:
- high-performance liquid chromatography
- Key result
- Type:
- Pow
- Partition coefficient:
- > 0
- Temp.:
- 30 °C
- pH:
- 6.92
- Key result
- Type:
- log Pow
- Partition coefficient:
- > 9.4
- Temp.:
- 30 °C
- pH:
- 6.92
- Conclusions:
- Under the conditions of the study, the partition coefficient of the test item has been determined to be greater than 2.51 x 10^9, log10 Pow >9.4.
- Executive summary:
Under the conditions of the study, the partition coefficient of the test item has been determined to be greater than 2.51 x 109, log10 Pow > 9.4, using the HPLC method, designed to be compatible with Method A.8 Partition Coefficient of Commission Regulation (EC) No 440/2008 of 30 May 2008, Method 117 of the OECD Guidelines for Testing of Chemicals, 13 April 2004 and Method 830.7570 of the OCSPP Guidelines, August 1996.
Reference
The result from the preliminary test indicated that the HPLC method was suitable for determination of partition coefficient for this test item.
Due to the high partition coefficient of the sample and that of the reference standards used, the aqueous portion of the mobile phase was lowered slightly to below the 25% stated in the method guidelines in order to elute the reference standards and sample within a reasonable timeframe. As the result is reported as a limit value this was considered not to impact the result.
Description of key information
Under the conditions of the study, the partition coefficient of the test item has been determined to be greater than 2.51 x 109, log(10) P(ow) > 9.4, using the HPLC method, designed to be compatible with Method A.8 Partition Coefficient of Commission Regulation (EC) No 440/2008 of 30 May 2008, Method 117 of the OECD Guidelines for Testing of Chemicals, 13 April 2004 and Method 830.7570 of the OCSPP Guidelines, August 1996.
Key value for chemical safety assessment
- Log Kow (Log Pow):
- 9.4
Additional information
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