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EC number: 947-655-7
CAS number: -
purpose of this study was to determine the potential of the test item,
containing 39.80% active ingredient, in guinea pigs in a test model
according to MAGNUSSON and KLIGMAN.
a preliminary experiment, it was decided to use a 0.5% concentration in
aqua ad iniectabilia for the 1st (intracutaneous) stage, a 25%
suspension in aqua ad iniectabilia for the 2nd (topical) induction stage
and a 10% suspension in aqua ad iniectabilia for the challenge.
0.5% suspension in aqua ad iniectabilia chosen for the 1st
(intracutaneous) induction stage revealed a discrete or patchy erythema
in all 10 animals 24 and 48 hours after administration. 2 mL of a 25%
suspension of the test item in aqua ad iniectabilia/animal chosen for
the 2nd (topical) induction stage revealed a moderate and confluent
erythema 48 hours and a discrete or patchy erythema 72 hours after start
of exposure in all 10 animals. The challenge with 2 mL of a 10%
suspension of the test item in aqua ad iniectabilia /animal - the
maximum non-irritating concentration - revealed no skin irritation in
any animal and, thus, the test item had no sensitising properties.
vehicle control revealed no skin reactions.
of the same strain treated with α-hexyl cinnamic aldehyde in sesame oil
exhibited a sensitising reaction in all animals in form of a moderate
and confluent erythema (grade 2).
of the animals remained unchanged. Body weights were not affected
the present test conditions, test item containing 39.8% active
ingredient, was found to be not sensitising to guinea pigs in a test
model according to MAGNUSSON and KLIGMAN.
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