Registration Dossier
Registration Dossier
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EC number: 816-326-9 | CAS number: 15517-46-1
Partition coefficient
Administrative data
Link to relevant study record(s)
- Endpoint:
- partition coefficient
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- From 27 September 2017 to 06 March 2018
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Reason / purpose for cross-reference:
- reference to other study
- Reason / purpose for cross-reference:
- reference to other study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 117 (Partition Coefficient (n-octanol / water), HPLC Method)
- Version / remarks:
- 2004
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- other: EC Guideline A.24. Partition Coefficient (n-octanol/water), High Performance Liquid Chromatography (HPLC) Method.
- Version / remarks:
- 2016
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EPA OPPTS 830.7570 (Partition Coefficient, n-octanol / H2O, Estimation by Liquid Chromatography)
- Version / remarks:
- 1996
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- HPLC method
- Partition coefficient type:
- octanol-water
- Analytical method:
- high-performance liquid chromatography
- Type:
- log Pow
- Partition coefficient:
- 2.4
- Temp.:
- 35 °C
- pH:
- 2
- Key result
- Type:
- log Pow
- Partition coefficient:
- 2.4
- Temp.:
- 35 °C
- pH:
- 7
- Details on results:
- Due to the presence of two phenol groups, the determination of the partition coefficient was performed at two pH values: pH 2 and pH 7. Indeed, according to the guidelines, the determination of the partition coefficient should be performed on its non-ionized form and preferably also for the dissociated form. At pH 2, the test item is present in its non-ionized form.
- Conclusions:
- The partition coefficient (log Pow) of the test item is 2.4 at pH 2 and pH 7
- Executive summary:
The partition coefficient (Pow) of the test item was determined by the HPLC method according to recognised guidelines and in compliance with GLP (Brekelmans, 2018). No deviation from the guidelines was observed during the test.
The test item log Pow is 2.4 at pH 2 and pH 7. Therefore the test item can be considered of low potential for bioaccumulation.
Reference
Description of key information
The partition coefficient of the test item was detemined in a key study of Klimisch validity 1 performed according to recognised guidelines and in compliance with GLP (Brekelmans, 2018).
No deviation from the guideline was observed in the study.
Key value for chemical safety assessment
- Log Kow (Log Pow):
- 2.4
- at the temperature of:
- 35 °C
Additional information
Based on its log Pow value, the test item is considered to present low potential for bioaccumulation.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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