Registration Dossier

Administrative data

Description of key information

Key value for chemical safety assessment

Skin sensitisation

Endpoint conclusion
Endpoint conclusion:
adverse effect observed (sensitising)
Additional information:

The delayed contact hypersensivity of DIBENZYL TRITHIOCARBONATE was evaluated in Guinea pigs according to OECD N°406 guideline (Magnusson and Kligman test) (Ollivier, 2004d).

The induction phase has been realized both by intradermal route on day 0.1 (% in vehicle) and by cutaneous route on day 50 (%) in 2 groups of guinea pigs: 5 males and 5 females for control group and 10 males and 10 females for treated group. The challenge phase was realized on day 22 by cutaneous application of 25 % on the right flank (vehicle on the left flank); the cutaneous reactions were scored 24 and 48 hours after the challenge phase.

After the challenge application, a discrete erythema was observed in 2/10 animals of the control group, at the 24-hour reading only.

In the treated group, a discrete or moderate erythema, together with an oedema in one animal, was noted at the 24-hour reading in 17/20 and 2/20 animals, respectively. At the 48-hour reading, a discrete or moderate erythema, together with dryness of the skin in two animals, persisted in 7/20 and 2/20 animals, respectively. The persistent cutaneous reactions observed in 9/20 animals of the treated group were attributed to delayed contact hypersensitivity.

Under the experimental conditions of the maximization method of Magnusson and Kligman, DIBENZYL TRITHIOCARBONATE induces delayed contact hypersensitivity in 9/20 (45%) guinea pigs, and should therefore be considered as a moderate sensitizer.

Migrated from Short description of key information:
According to the maximization method of Magnusson and Kligman, DIBENZYL TRITHIOCARBONATE is considered as a moderate sensitizer

Justification for classification or non-classification

According to REGULATION (EC) No 1272/2008 OF THE EUROPEAN PARLIAMENT AND OF THE COUNCIL of 16 December 2008, DIBENZYL TRITHIOCARBONATE must be classified as skin senzitizer (may cause an allergic skin reaction).