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Particle size distribution (Granulometry)

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Reference
Endpoint:
particle size distribution (granulometry)
Type of information:
experimental study
Adequacy of study:
key study
Study period:
12.-30.10.2017
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Qualifier:
according to
Guideline:
OECD Guideline 110 (Particle Size Distribution / Fibre Length and Diameter Distributions) - Method B: Fibre Length and Diameter Distributions
GLP compliance:
no
Type of method:
Laser scattering/diffraction
Type of particle tested:
primary particle
Type of distribution:
volumetric distribution
Key result
Percentile:
D50
Mean:
33 µm
Remarks on result:
other: no SD indicated
Percentile:
D10
Mean:
12 µm
Remarks on result:
other: no SD indicated
Percentile:
D90
Mean:
89 µm
Remarks on result:
other: no SD indicated

The test item consisted of transparent irregular shaped particles. After adjusting the laser, measuring the background and adjusting the correct particle concentration (obscuration) the measurement was started. The control software automatically performed three measurements. The average of these three measurements was given as result. Two test series of three measurements each were performed. The measurement time was 12 s.

The median particle size D50: 50 % of particle volume or particle mass with lower particle diameter) deduced from these distributions are:

1st test series: D50 = 33.4 µm

2nd test series: D50 = 27.7 µm

The average of the median particle size D50 is 33 µm.

 

The particle size D10: 10 % of particle volume or particle mass with lower particle diameter) deduced from these distributions are:

1st test series: D10 = 12.0 µm

2nd test series: D10= 10.2 µm

The average of the particle size D10 is 12 µm.

 

The particle size D90: 90 % of particle volume or particle mass with lower particle diameter) deduced from these distributions are:

1st test series: D90 = 88.8 µm

2nd test series: D90 = 67.3 µm

The average of the particle size D90 = 89 µm.

 

The measurements showed a decreasing tendency. Another measurement without the use of ultrasound was not possible as the test item formed agglomerates. These agglomerates could not be broken up without or even with less ultrasound. It cannot be excluded that the test item would also get smaller under normal conditions (e.g. processing, transport). The particle size distribution showed a polymodal distribution. The maxima were observed at approximately 1 µm, 4 µm and 30 µm. The first measurement showed a fourth maximum at approximately 500 µm.

Conclusions:
The median particle size D50 of the test item deduced from the particle size distributions was determined to be 33 µm.
Executive summary:

A study was conducted according to OECD TG 110, OPPTS 830.7520 and ISO 13320 in order to determine the particle size distribution of the test item. The particle size distribution was determined using laser diffraction. Two test series of 3 measurements each were performed with the test item. The maxima were observed at approximately 1 µm, 4 µm and 30 µm. The median particle size D50 of the test item was determined to be 33 µm. The particle size D10 of the test item was determined to be 12 µm and the D90 was determined to be 89 µm, respectively.

Description of key information

The median particle size D50 of the test item deduced from the particle size distributions was determined to be 33 µm (reference 4.5 -1).

Additional information

A study was conducted according to OECD TG 110, OPPTS 830.7520 and ISO 13320 in order to determine the particle size distribution of the test item. The particle size distribution was determined using laser diffraction. Two test series of 3 measurements each were performed with the test item.The maxima were observed at approximately 1 µm, 4 µm and 30 µm.The median particle size D50 of the test item was determined to be 33 µm. The particle size D10 of the test item was determined to be 12 µm and the D90 was determined to be 89 µm, respectively.