Registration Dossier
Registration Dossier
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EC number: 412-830-4 | CAS number: 1823-59-2 ODPA
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
Data source
Reference
- Reference Type:
- secondary source
- Title:
- Unnamed
- Year:
- 1 992
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- EU Method B.4 (Acute Toxicity: Dermal Irritation / Corrosion)
- GLP compliance:
- yes
Test material
- Reference substance name:
- 4,4'-oxydiphthalic anhydride
- EC Number:
- 412-830-4
- EC Name:
- 4,4'-oxydiphthalic anhydride
- Cas Number:
- 1823-59-2
- Molecular formula:
- C16H6O7
- IUPAC Name:
- 5-[(1,3-dioxo-1,3-dihydro-2-benzofuran-5-yl)oxy]-1,3-dihydro-2-benzofuran-1,3-dione
- Test material form:
- solid: particulate/powder
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
Test system
- Type of coverage:
- occlusive
- Vehicle:
- other: acetone
- Amount / concentration applied:
- 500 mg
- Duration of treatment / exposure:
- 24h
- Number of animals:
- 6
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- erythema score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 0
- Reversibility:
- fully reversible
- Remarks on result:
- no indication of irritation
- Irritation parameter:
- edema score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 0
- Reversibility:
- fully reversible
- Remarks on result:
- no indication of irritation
- Irritant / corrosive response data:
- Two animals showed very slight erythema (score of 1) one hour after patch removal.
The effects were however fully reversible within 1 day.
Any other information on results incl. tables
Although a longer exposure time than required by Annex V was employed, the UK c.a. considered the text to be acceptable.
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- Not classifed.
- Executive summary:
In a test according to EU Method B.4, the test item was found to cause very slight erythema one hour after patch removal. The effects were fully reversible within 1 day.
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