Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
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EC number: 210-498-3 | CAS number: 616-91-1
Endpoint summary
Administrative data
Description of key information
Additional information
Table 1: Human data
Source |
Observation |
Concentration |
David J. et al., Liver Injury After Oral and Rectal Administration of N-Acetylcysteine for Meconium Ileus Equivalent in a Patient With Cystic Fibrosis, Pediatrics February 1987, VOLUME 79 / ISSUE 2 |
A 3-year old boy was treated with the test via different routes for 3 days. Severe hepatic dysfunction occurred on two occasions after the administration of NAC for the treatment of meconium ileus equivalent. |
TDLo = 8480 mg/kg |
van Zandwijk N. et al., EUROSCAN, a randomized trial of vitamin A and N-acetylcysteine in patients with head and neck cancer or lung cancer. For the European Organization for Research and Treatment of Cancer Head and Neck and Lung Cancer Cooperative Groups. J Natl Cancer Inst. 2000 Jun 21;92(12):977-86. |
Human, 2-year administration; route not reported |
TDLo = 3650 mg/kg |
Cancer Epidemiology Biomarkers & Prevention,11,167, 2002 |
human, oral administration, 24 weeks |
TDLo = 1.54 g/kg |
Kim J., et al (correspondence). Response to Letter to the Editor on "Effect of N-acetylcysteine on liver recovery after resection. A randomized clinical trial". Journal of Surgical Oncology, (1 Nov 2016) Vol. 114, No. 6, pp. 774. Refs: 2 ISSN: 0022-4790; E-ISSN: 1096-9098 CODEN: JSONAU |
Human, occupational contact dermatitis in adults |
|
Beuhler, Michael C., Dr. (correspondence), Dulaney, Anna R. Further case details regarding IV N-acetylcysteine overdoses. Clinical Toxicology, (November 2011) Vol. 49, No. 9, pp. 878. Refs: 3 ISSN: 1556-3650; E-ISSN: 1556-9519 |
Human, occupational contact dermatitis, effects of overdose |
|
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