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Hazard for aquatic organisms

Hazard for air

Hazard for terrestrial organisms

Hazard for predators

Additional information

Conclusion on classification

Two study reports (rated as Klimisch 1) on aquatic organisms are available covering two trophic levels: a primary producer (freshwater algae, represented by the model species Pseudokirchneriella subcapitata) and a primary consumer (aquatic invertebrates, represented by the model species Daphnia magna).

 

D. magna was exposed for 48 hours to 4,4'-Dimethoxytrityl chloride in a static short-term GLP toxicity study (OECD 202) at a limit concentration of 4.3 mg/L (measured, limit of water solubility, loading 100 mg/L nominal). No effect on D. magna was observed. The test concentration was determined analytically by HPLC-UV. Therefore, 4,4'-Dimethoxytrityl chloride is not toxic to D. magna up to the limit of water solubility.

 

The freshwater algae P. subcapitata was exposed to 4,4'-Dimethoxytrityl chloride for 72 hours in a GLP toxicity study (OECD 201). In this study a 72 h ErC50(endpoint: growth rate) of 1.629 mg/L (95 % C.L. 1.079 – 2.417 mg/L) and a 72 h NOErC (endpoint: growth rate) of 0.537 mg/L were determined. The test concentrations were determined analytically by HPLC-UV. 

 

Taking into account that 4,4'-Dimethoxytrityl chloride is considered to be not readily biodegradable based on ThCO2. (Flach 2018) and the lowest effect value was determined to be > 1 mg/L (ErC50 = 1.629 mg/L), 4,4'-Dimethoxytrityl chloride has to be classified as "Aquatic Chronic 2" (H411) following the provisions laid down in the CLP Regulation (Regulation (EC) No 1272/2008).