Registration Dossier
Registration Dossier
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EC number: 229-227-5 | CAS number: 6441-82-3
Skin sensitisation
Administrative data
- Endpoint:
- skin sensitisation: in vivo (non-LLNA)
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- secondary literature
- Justification for type of information:
- Data is from secondary source .
Data source
Reference
- Reference Type:
- secondary source
- Title:
- Determination of skin sensitization for 91-68-9
- Author:
- IUCLI D ATASET
- Year:
- 2 000
- Bibliographic source:
- EUROPEAN COMMISSION – European Chemicals Bureau
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: As mentioned below
- Principles of method if other than guideline:
- Skin sensitization study of 3–diethylaminophenol was conducted in guinea pigs to determine its sensitization efficacy.
- GLP compliance:
- not specified
- Type of study:
- skin painting test
- Justification for non-LLNA method:
- not specified
Test material
- Reference substance name:
- 3–diethylaminophenol
- IUPAC Name:
- 3–diethylaminophenol
- Reference substance name:
- 91–68–9
- IUPAC Name:
- 91–68–9
- Reference substance name:
- 202–090–9
- IUPAC Name:
- 202–090–9
- Test material form:
- not specified
- Details on test material:
- Details on test material
- Name of test material (as cited in study report):
- Molecular formula: C10H15NO
- Molecular weight: 165.234g/mol
- Substance type: Organic
Constituent 1
Constituent 2
Constituent 3
- Specific details on test material used for the study:
- Details on test material
- Name of test material (as cited in study report): 3–diethylaminophenol
- Molecular formula (if other than submission substance): C10H15NO
- Molecular weight (if other than submission substance): 165.234g/mol
- Substance type: Organic
In vivo test system
Test animals
- Species:
- guinea pig
- Strain:
- not specified
- Sex:
- not specified
- Details on test animals and environmental conditions:
- No data available.
Study design: in vivo (non-LLNA)
Induction
- Route:
- other: No data
- Vehicle:
- no data
- Concentration / amount:
- No data available
Challenge
- Route:
- other: No data
- Vehicle:
- no data
- Concentration / amount:
- No data available
- No. of animals per dose:
- No data available.
- Details on study design:
- No data available.
Study design: in vivo (LLNA)
- Statistics:
- No data available.
Results and discussion
In vivo (non-LLNA)
Results
- Reading:
- 1st reading
- Group:
- test chemical
- No. with + reactions:
- 0
- Clinical observations:
- not sensitizing
- Remarks on result:
- no indication of skin sensitisation
Applicant's summary and conclusion
- Interpretation of results:
- other: not sensitising
- Conclusions:
- The test material 3–diethylaminophenol (CAS No: 91-68-9) was observed to be non sensitizing to guinea pigs.
- Executive summary:
The skin sensitization study of 3–diethylaminophenol(CAS No: 91-68-9)was performed in guinea pigs to observed its sensitizing potential.The guinea pigs did not produce any sensitization potential .Thus3–diethylaminophenolwas considered to be non sensitizing to the guinea pigs.
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