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EC number: 947-255-2 | CAS number: -
In a reverse gene mutation assay in bacteria, performed according to the OECD Guideline 471 and in compliance with GLP, strains ofSalmonella typhimurium(TA1535, TA1537, TA98, TA100) and E.coli WP2 were exposed to test item Ravintsara essential oil at the following concentrations:
- TA1535, TA1537, TA98, TA100 and E.coli WP2: 50, 150, 500, 1500, 3500 and 5000 μg/plate, with and without S9-mix
Metabolic activation system used in this test 10 % S9 mix; S9 fraction prepared from liver homogenates of male Sprague Dawley rats . Vehicle, negative and positive control groups were also included in mutagenicity tests.
Following treatment, evidence of toxicity was observed at 5000 μg/plate in strains TA 98, TA1535 and TA 1537 in the absence and presence of S-9.
The mean numbers of revertant colonies felt within acceptable historical ranges for vehicle control treatments, and were significantly elevated by positive control treatments.
No significant increases in the frequency of revertant colonies were recorded for any of the bacterial strains, at any dose level either with or without metabolic activation.
Under the test conditions, the test item is not considered as mutagenic in S. typhimurium TA 1535, TA 1537, TA 98, TA 100 and in Escherichia coli WP2 (uvrA-) (pKM 101) strains without or with metabolic activation.
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