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EC number: 257-885-3 | CAS number: 52372-39-1
Endpoint summary
Administrative data
Description of key information
Biodegradation in water
Estimation Programs Interface Suite was run to predict the biodegradation potential of the test compound 3 -(diethylamino)-7 -imino-7H-chromeno[3',2':3,4]pyrido[1,2 -a]benzimidazole-6 -carbonitrile (CAS no. 52372 -39 -1) in the presence of mixed populations of environmental microorganisms. The biodegradability of the substance was calculated using seven different models such as Linear Model, Non-Linear Model, Ultimate Biodegradation Timeframe, Primary Biodegradation Timeframe, MITI Linear Model, MITI Non-Linear Model and Anaerobic Model (called as Biowin 1-7, respectively) of the BIOWIN v4.10 software. The results indicate that chemical 3 -(diethylamino)-7 -imino-7H-chromeno[3',2':3,4]pyrido[1,2 -a]benzimidazole-6 -carbonitrile is expected to be not readily biodegradable.
Additional information
Biodegradation in water
Predicted data for the target compound 3-(diethylamino)-7-imino-7H-chromeno[3',2':3,4]pyrido[1,2-a]benzimidazole-6-carbonitrile (CAS No. 52372-39-1) and various supporting weight of evidence studies for its structurally and functionally similar read across substance were reviewed for the biodegradation end point which are summarized as below:
In a prediction using the Estimation Programs Interface Suite (2018), the biodegradation potential of the test compound 3 -(diethylamino)-7 -imino-7H-chromeno[3',2':3,4]pyrido[1,2 -a]benzimidazole-6 -carbonitrile (CAS No. 52372-39-1) in the presence of mixed populations of environmental microorganisms was estimated.The biodegradability of the substance was calculated using seven different models such as Linear Model, Non-Linear Model, Ultimate Biodegradation Timeframe, Primary Biodegradation Timeframe, MITI Linear Model, MITI Non-Linear Model and Anaerobic Model (called as Biowin 1-7, respectively) of the BIOWIN v4.10 software. The results indicate that chemical 3 -(diethylamino)-7 -imino-7H-chrome no[3',2':3,4]pyrido[1,2 -a]benzimidazole-6 -carbonitrile is expected to be not readily biodegradable.
For the test chemical, biodegradation study was conducted for 5 days for evaluating the percentage biodegradability of test substance using standard dilution method at a temperature of 20°C (H. Heukelekian et. al., 1955). Sewage was used as a test inoculum. The 5 day BOD value of test chemical was determined to be 0 g/g. Thus, based on this value, test substance is considered to be not readily biodegradable in nature.
In a supporting weight of evidence study from authoritative database (2017) for the test chemical,biodegradation study was conducted for 14 days for evaluating the percentage biodegradability of test substance. Concentration of inoculum i.e, sludge used was 30 mg/l and initial test substance conc. used in the study was 100 mg/l, respectively. The percentage degradation of test substance was determined to be 0% by BOD parameter in 14 days. Thus, based on percentage degradation, test chemical is considered to be not readily biodegradable in nature.
Another biodegradation study was conducted for 5 days for evaluating the percentage biodegradability of test chemical. Sewage sludge was used as a test inoculum. The percentage degradation of test substance was determined to be 5% by BOD parameter in 5 days. Thus, based on percentage degradation, test chemical is considered to be not readily biodegradable in nature.
In a supporting weight of evidence study from authoritative database (2017) for the test chemical,biodegradation experiment was conducted for 28 days for evaluating the percentage biodegradability of test substance. Activated sludge (non-adapted) was used as a test inoculums for the study. Concentration of inoculum i.e, sludge used was 30 mg/l and initial test substance conc. used in the study was 100 mg/l, respectively. The percentage degradation of test substance was determined to be 1% by BOD and HPLC parameter in 28 days. Thus, based on percentage degradation, test chemical is considered to be not readily biodegradable in nature.
On the basis of above results for target chemical 3-(diethylamino)-7-imino-7H-chromeno[3',2':3,4]pyrido[1,2-a]benzimidazole-6-carbonitrile (from modelling database, 2018), it can be concluded that the test substance 3-(diethylamino)-7-imino-7H-chromeno[3',2':3,4]pyrido[1,2-a]benzimidazole-6-carbonitrile can be expected to be not readily biodegradable in nature.
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