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Toxicological information

Skin irritation / corrosion

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Administrative data

Endpoint:
skin irritation: in vivo
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
data from handbook or collection of data
Justification for type of information:
data is from peer reviewed journals

Data source

Reference
Reference Type:
publication
Title:
Safety assessment of Dialkyl hydroxysuccinates as used in cosmetics
Author:
Cosmetic Ingredient Review Expert Panel
Year:
2011
Bibliographic source:
Cosmetic Ingredient Review, 2011

Materials and methods

Test guideline
Qualifier:
according to
Guideline:
other: Draize method
Principles of method if other than guideline:
To assess the dermal irritation potential of the test chemical in rabbits
GLP compliance:
not specified

Test material

Reference
Name:
Unnamed
Type:
Constituent
Test material form:
solid
Details on test material:
Name of the test chemical: (2R,3R)-(+)-Tartaric acid
Molecular Weight: 150.09 g/mol
Molecular Formula:C4H6O6
Substance Type:Organic
Physical State: Solid

Test animals

Species:
rabbit
Strain:
other: Japanese White

Test system

Type of coverage:
occlusive
Preparation of test site:
clipped
Vehicle:
water
Controls:
not specified
Amount / concentration applied:
0.5 ml of 1.8% aqueous solution
Duration of treatment / exposure:
24 hours
Observation period:
24, 48, and 72 h after dosing
Number of animals:
3
Details on study design:
no data available

Results and discussion

In vivo

Results
Irritation parameter:
overall irritation score
Basis:
mean
Time point:
48 h
Score:
0
Reversibility:
not specified
Remarks on result:
no indication of irritation
Irritant / corrosive response data:
No signs of irritation observed

Applicant's summary and conclusion

Interpretation of results:
other: not irritating
Conclusions:
No Signs of irritation were observed. The Draize score was 0.
Hence, the test chemical was considered to be not irritating to skin.
Executive summary:

The dermal irritation potential of the test chemical was assessed in rabbits.0.5 ml of 1.8% aqueous solution was applied under occlusion to the clipped skin of 3 Japanese White rabbits for 24 hours. The treated skin was observed at1, 24 and 48 hours.

No signs of irritation were observed. The Draize score was 0.

Hence, the test chemical was considered to be not irritating to skin.