Registration Dossier
Registration Dossier
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EC number: 284-628-2 | CAS number: 84961-40-0
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1981
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 981
- Report date:
- 1981
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- GLP compliance:
- no
- Remarks:
- prior to GLP implementation
- Limit test:
- no
Test material
- Reference substance name:
- Amines, C10-14-branched and linear alkyl, bis[2,4-dihydro-4-[(2-hydroxy-5-nitrophenyl)azo]-5-methyl-2-phenyl-3H-pyrazol-3-onato(2-)]chromate(1-) (1:1)
- EC Number:
- 284-628-2
- EC Name:
- Amines, C10-14-branched and linear alkyl, bis[2,4-dihydro-4-[(2-hydroxy-5-nitrophenyl)azo]-5-methyl-2-phenyl-3H-pyrazol-3-onato(2-)]chromate(1-) (1:1)
- Cas Number:
- 84961-40-0
- Molecular formula:
- C32H22CrN10O8.C10-14H21-29NH2
- IUPAC Name:
- Amines, C10-14-branched and linear alkyl, bis[2,4-dihydro-4-[(2-hydroxy-5-nitrophenyl)azo]-5-methyl-2-phenyl-3H-pyrazol-3-onato(2-)]chromate(1-) (1:1)
- Test material form:
- solid
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Fasting period before study: food depreviation 15 - 20 hours before test substance administration.
- Diet: standardized animal laboratory diet
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- olive oil
- Details on oral exposure:
- Form of administration: suspension
Concentrations used: 16.5, 24.2, 35.6 % (w/v)
Administration volume: 5, 7.3, 10.8 mL/kg - Doses:
- 825, 1210, 1780, 2610, 3830 mg/kg bw
- No. of animals per sex per dose:
- 5
- Details on study design:
- - Duration of observation period following administration: 14 days
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs, body weight
Results and discussion
Effect levels
- Key result
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- ca. 1 400 mg/kg bw
- Mortality:
- Males: 825 mg/kg: no deaths; 1210 mg/kg: 3/5 after 14 days; 1780 mg/kg: 1/5 after 14 days; 2610 mg/kg: 4/5 after 14 days; 3830 mg/kg: 5/5 after 14 days
Females: 825 mg/kg: no deaths; 1210 mg/kg: 3/5 after 14 days; 1780 mg/kg: 4/5 after 14 days; 2610 and 3830 mg/kg: 5/5 after 14 days - Clinical signs:
- other: Dyspnea, apathy, staggering, feces and urine orange-coloured, diarrhea, poor general state
- Gross pathology:
- Died animals:
heart: acute dilatation of the atrium; acute congestive hyperemia
organs/fat tissues/musculature: substance-coloured
Sacrificed animals:
organs: nothing abnormal detected
Applicant's summary and conclusion
- Interpretation of results:
- Category 4 based on GHS criteria
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