Registration Dossier
Registration Dossier
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EC number: 274-668-9 | CAS number: 70546-25-7
Partition coefficient
Administrative data
Link to relevant study record(s)
- Endpoint:
- partition coefficient
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2017-06-26 until 2017-11-02
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 117 (Partition Coefficient (n-octanol / water), HPLC Method)
- Qualifier:
- according to guideline
- Guideline:
- other: SOP 00187 Version 3
- Version / remarks:
- Internal method for determination of the partition coefficients
- Qualifier:
- according to guideline
- Guideline:
- other: SOP 00178 Version 3
- Version / remarks:
- Internal method for determination of the pH value
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- HPLC method
- Partition coefficient type:
- octanol-water
- Analytical method:
- high-performance liquid chromatography
- Type:
- log Pow
- Partition coefficient:
- 5.2
- Temp.:
- 25 °C
- pH:
- 7.2
- Details on results:
- The result is the mean value out of three individual measurements. In order to ensure a stable performance of the HPLC column, the column temperature was set to 40 °C. It is assumed that the reference Pow-values in the OECD guideline refer to 25 °C. Even though the column temperature was 40 °C, this temperature has only a negligible influence on the result of the determination. Therefore the Pow-value of the test item determined within this study also refers to 25 °C.
- Conclusions:
- The logPow of Macrolex Fluoreszenzrot G is determined to be 5.2 at 25°C and a pH of 7.2.
- Executive summary:
The partition coefficient of Macrolex Fluoreszenzrot G was determined by the HPLC-method according to OECD Guideline TG 117. The partition coefficient was found to be log Pow = 5.2 at a pH = 7.2 and 25°C.
Reference
The log Pow value was calculated with the standard software KOWWIN v1.68 assuming the nonionic form. KOWWIN is owned by the U.S. Environmental Protection Agency. For the test item Macrolex Fluoreszenzrot G, the calculated partition coefficient is: log Pow = 3.7. This calculation of the partition coefficient served as a preliminary estimation only.
Description of key information
The logPow of Macrolex Fluoreszenzrot G is determined to be 5.2 at 25°C and a pH of 7.2.
Key value for chemical safety assessment
- Log Kow (Log Pow):
- 5.2
- at the temperature of:
- 25 °C
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
