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Toxicological information

Skin irritation / corrosion

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Administrative data

Endpoint:
skin irritation: in vitro / ex vivo
Type of information:
experimental study
Adequacy of study:
weight of evidence
Study period:
in vitro skin irritation
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
data from handbook or collection of data
Justification for type of information:
A review of taurine and its salts, including those of secondary amines
Work is to support use of these amino acid derivatives in cosmetics
Limited data on the animal work performed historically, but conclusion is that these are not potential for skin irritation

Data source

Reference
Reference Type:
review article or handbook
Title:
Safety Assessment of Alkyl Taurate Amides and Taurate Salts as Used in Cosmetics
Author:
Cosmetic Ingredient Review
Year:
2015
Bibliographic source:
Cosmetic Ingredient Review, 2015

Materials and methods

Test guideline
Qualifier:
equivalent or similar to
Guideline:
OECD Guideline 439 (In Vitro Skin Irritation: Reconstructed Human Epidermis Test Method)
GLP compliance:
not specified

Test material

Reference
Name:
Unnamed
Type:
Constituent
Specific details on test material used for the study:
Note that the review covers taurine and derivates; testing appears to have been performed on salts, but the review concludes that these can all be groups for evaluation purposes.

In vitro test system

Test system:
human skin model

Test system

Type of coverage:
not specified
Preparation of test site:
not specified
Vehicle:
water
Amount / concentration applied:
10 mg in 5 µL sterile water to wet the test substance; >90% pure

Results and discussion

In vitro

Results
Irritation / corrosion parameter:
% tissue viability
Value:
100
Negative controls valid:
not specified
Positive controls valid:
not specified

Applicant's summary and conclusion

Interpretation of results:
GHS criteria not met
Conclusions:
A review of taurine and its salts, including those of secondary amines
Work is to support use of these amino acid derivatives in cosmetics
Limited data on the animal work performed historically, but conclusion is that these are not potential for skin irritation