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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Genetic toxicity: in vitro

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Administrative data

Endpoint:
in vitro gene mutation study in bacteria
Type of information:
experimental study
Adequacy of study:
disregarded due to major methodological deficiencies
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
secondary literature

Data source

Referenceopen allclose all

Reference Type:
review article or handbook
Title:
CICAD 29: Vanadium pentoxide and other inorganic vanadium compounds
Author:
Dr M. Costigan, Mr R. Cary, Dr S. Dobson
Year:
2001
Bibliographic source:
World Health Organization
Reference Type:
publication
Title:
Mutagenicity test data of existing chemical substances
Author:
JETOC
Year:
1996
Bibliographic source:
Japan Chemical Industry Ecology-Toxicology & Informaton Centre

Materials and methods

Principles of method if other than guideline:
No details
GLP compliance:
not specified

Test material

Constituent 1
Chemical structure
Reference substance name:
Vanadium trichloride
EC Number:
231-744-6
EC Name:
Vanadium trichloride
Cas Number:
7718-98-1
Molecular formula:
Cl3V
IUPAC Name:
vanadium trichloride
Details on test material:
No details
Specific details on test material used for the study:
No details

Method

Target gene:
No details
Species / strainopen allclose all
Species / strain / cell type:
S. typhimurium TA 1535, TA 1537, TA 98, TA 100 and E. coli WP2
Details on mammalian cell type (if applicable):
No details
Additional strain / cell type characteristics:
not specified
Species / strain / cell type:
S. typhimurium TA 1538
Details on mammalian cell type (if applicable):
No details
Additional strain / cell type characteristics:
not specified
Metabolic activation:
with and without
Metabolic activation system:
No details
Test concentrations with justification for top dose:
Between 1 and 200 µg/ plate
Vehicle / solvent:
No details
Details on test system and experimental conditions:
No details
Rationale for test conditions:
No details
Evaluation criteria:
No details
Statistics:
No details

Results and discussion

Test resultsopen allclose all
Species / strain:
S. typhimurium TA 1535
Metabolic activation:
with and without
Genotoxicity:
negative
Cytotoxicity / choice of top concentrations:
not specified
Vehicle controls validity:
not specified
Untreated negative controls validity:
not specified
Positive controls validity:
not specified
Species / strain:
S. typhimurium TA 98
Metabolic activation:
with and without
Genotoxicity:
negative
Cytotoxicity / choice of top concentrations:
not specified
Vehicle controls validity:
not specified
Untreated negative controls validity:
not specified
Positive controls validity:
not specified
Species / strain:
S. typhimurium TA 100
Metabolic activation:
with and without
Genotoxicity:
negative
Cytotoxicity / choice of top concentrations:
not specified
Vehicle controls validity:
not specified
Untreated negative controls validity:
not specified
Positive controls validity:
not specified
Species / strain:
S. typhimurium TA 1537
Metabolic activation:
with and without
Genotoxicity:
not specified
Cytotoxicity / choice of top concentrations:
not specified
Vehicle controls validity:
not specified
Untreated negative controls validity:
not specified
Positive controls validity:
not specified
Species / strain:
S. typhimurium TA 1538
Metabolic activation:
with and without
Genotoxicity:
negative
Cytotoxicity / choice of top concentrations:
not specified
Vehicle controls validity:
not specified
Untreated negative controls validity:
not specified
Positive controls validity:
not specified
Species / strain:
E. coli WP2 uvr A
Metabolic activation:
with and without
Genotoxicity:
negative
Cytotoxicity / choice of top concentrations:
not specified
Vehicle controls validity:
not specified
Untreated negative controls validity:
not specified
Positive controls validity:
not specified
Additional information on results:
No details

Applicant's summary and conclusion

Conclusions:
One Ames test has been performed with vanadium trichloride. Negative results were obtained, in the presence and absence of metabolic activation, at concentrations between 1 and 200 μg/plate with Salmonella typhimurium strains TA98, TA100, TA1535, TA1537, and TA1538 and Escherichia coli WP2uvrA.
Executive summary:

One Ames test has been performed with vanadium trichloride. Negative results were obtained, in the presence and absence of metabolic activation, at concentrations between 1 and 200 μg/plate with Salmonella typhimurium strains TA98, TA100, TA1535, TA1537, and TA1538 and Escherichia coli WP2uvrA.