Registration Dossier
Registration Dossier
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EC number: 280-734-8 | CAS number: 83763-48-8
Hydrolysis
Administrative data
Link to relevant study record(s)
Description of key information
The test item was determined to be unstable in sterile aqueous solutions buffered at pH levels of 4, 7, and 9 after incubation for 5 days at 50 ± 0.5 °C. The test substance had fully degraded by Day 5 at pH 4, and had a half-life of 1.1 and 4.3 days at pH 7 and 9, respectively.
Key value for chemical safety assessment
- Half-life for hydrolysis:
- 1.1 d
- at the temperature of:
- 50 °C
Additional information
The test item was tested for hydrolysis according to the OECD Guideline 111 and GLP. The hydrolysis of the test item was studies after 5 days at 50°C and pH 4, 7 and 9.
After five days, at pH 4 the measured concentrations were < LOQ and so the percentage recovery cannot be calculated.
After five days, the percent of initial sample recovered in the pH 7 samples was 3.8 and 4.8%, respectively. After five days, the percent of initial sample recovered in the pH 9 samples was 46.8 and 42.3%, respectively.
The test item was determined to be unstable in sterile aqueous solutions buffered at pH levels of 4, 7, and 9 after incubation for 5 days at 50 ± 0.5 °C. The test substance was fully degraded by Day 5 at pH 4, and had a half-life of 1.1 and 4.3 days at pH 7 and 9, respectively.
This study satisfies the guideline requirements of the preliminary study of the OECD guideline 111.
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