Registration Dossier

Ecotoxicological information

Short-term toxicity to aquatic invertebrates

Administrative data

Endpoint:
short-term toxicity to aquatic invertebrates
Type of information:
(Q)SAR
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Justification for type of information:
QSAR prediction: migrated from IUCLID 5.6

Data source

Reference
Reference Type:
other: QSAR Toolbox
Title:
Unnamed
Year:
2015
Report Date:
2015

Materials and methods

Test guideline
Guideline:
other: REACH guidance on QSARs R.6, May/July 2008
Principles of method if other than guideline:
General model for narcosis (polar and non-polar)

Test material

Reference
Name:
Unnamed
Type:
Constituent
Test material form:
other: liquid

Results and discussion

Effect concentrations
Duration:
48 h
Dose descriptor:
EC50
Remarks:
Daphnia magna
Effect conc.:
11.9 mg/L

Any other information on results incl. tables

EC50 Daphnia magna (48h) of 1,6 -hexandiol dimethacrylate (11.2 mg/L) is predicted from category members (Methacrylates with an unspefic mechanism) using trend analysis based on 12 values within the range 2.57 - 380 mg/L from 12 category members. Category members are single chemicals and are selected based on the profile of the target chemical. Only chemicals having

experimental data are listed in the category. The target chemical FALLS within applicability domain of the prediction. The data used for calculating the current prediction is taken from 12 experimental values selected from the following database(s): 1. ECHA CHEM

Applicant's summary and conclusion

Conclusions:
EC50 Daphnia magna (48h): 11.2 mg/l predected based on QSAR
Executive summary:

EC50 Daphnia magna (48h) of 1,6 -hexandiol dimethacrylate (11.2 mg/L) is predicted from category members (Methacrylates with an unspefic mechanism) using trend analysis based on 12 values within the range 2.57 - 380 mg/L from 12 category members. Category members are single chemicals and are selected based on the profile of the target chemical. Only chemicals having

experimental data are listed in the category. The target chemical FALLS within applicability domain of the prediction. The data used for calculating the current prediction is taken from 12 experimental values selected from the following database(s): ECHA CHEM