Registration Dossier

Administrative data

Hazard for aquatic organisms

Freshwater

Hazard assessment conclusion:
PNEC aqua (freshwater)
PNEC value:
4.88 µg/L
Assessment factor:
100
Extrapolation method:
assessment factor
PNEC freshwater (intermittent releases):
45 µg/L

Marine water

Hazard assessment conclusion:
PNEC aqua (marine water)
PNEC value:
0.488 µg/L
Assessment factor:
1 000
Extrapolation method:
assessment factor

STP

Hazard assessment conclusion:
PNEC STP
PNEC value:
800 mg/L
Assessment factor:
1
Extrapolation method:
assessment factor

Sediment (freshwater)

Hazard assessment conclusion:
PNEC sediment (freshwater)
PNEC value:
0.262 mg/kg sediment dw
Extrapolation method:
equilibrium partitioning method

Sediment (marine water)

Hazard assessment conclusion:
PNEC sediment (marine water)
PNEC value:
0.026 mg/kg sediment dw
Extrapolation method:
equilibrium partitioning method

Hazard for air

Air

Hazard assessment conclusion:
no hazard identified

Hazard for terrestrial organisms

Soil

Hazard assessment conclusion:
PNEC soil
PNEC value:
0.05 mg/kg soil dw
Extrapolation method:
equilibrium partitioning method

Hazard for predators

Secondary poisoning

Hazard assessment conclusion:
no potential for bioaccumulation

Additional information

Conclusion on classification

1,6-HDDMA is readily biodegradable but log Pow is > 4,0. Acute toxicity data (based on experimental test or QSAR) are available for all three trophic levels. Chronic data were predicted by QSAR for algae and daphnia. Based on acute toxicity data fish and algae are the most sensitive species within the same range of toxicity. Classification is based on the NOEC algae (72h), QSAR: 0,488 mg/l into category chronic 3, H412. Chronic data fish are available for the more hydrophobic member of the category, TMPTMA, where NOEC fish (32d) was 0.138 mg/l. As 1,6-HDDMA Chronic 3, H412 hydrophobic and the toxicity is based on narcosis a NOEC fish less than 0.1 mg/l is not expected.

Therefore, based on log Pow and NOEC chronic 0,1 - <= 1 mg/l, 1,6-HDDMA will be classified into category chronic 3, H412.