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Diss Factsheets
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EC number: - | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Adsorption / desorption
Administrative data
Link to relevant study record(s)
Description of key information
The test substance eluted as three peaks and the corresponding Log Koc for the test substance by UV ranged from unretained (< urea) to 4.43 (OECD 117 and EU Method C.19).
Key value for chemical safety assessment
- Koc at 20 °C:
- 26 915
Additional information
GUIDELINE
The study was based on procedures in the OECD Guideline for the Testing of Chemicals, 121,Estimation of the Adsorption Coefficient (Koc) on Soil and on Sewage Sludge using,High Performance Liquid Chromatography (HPLC)and Official Journal of the European Communities No. L225 Method C.19: Estimation of the Adsorption Coefficient on Soil and Sewage Sludge using High Performance Liquid Chromatography (HPLC).
METHODS
Five calibration standards of known log Koc were prepared from reference materials in the respective mobile phase at a nominal concentration range (10.0 to 200 mg/L) selected to provide desired ultraviolet (UV) detector response. Capacity factors were calculated for the five calibration standards using a sixth calibration standard, urea, to estimate the column dead time (i.e. the retention time of an unretained organic compound). The logarithms of the capacity factors were then plotted against published log Koc values for the five calibration standards with known log Koc to establish a linear regression equation.
Test substance solutions were prepared at nominal concentrations of 1.00 mg/mL and 5.00 mg/mL in 55% methanol (MeOH): 45% HPLC-grade reagent water (H2O). The calibration standard preparations were sequentially injected into the HPLC system followed by a single injection of the matrix blank preparation, single injections of each of the three 1.00 mg/mL test substance preparations, and a single injection of the 5.00 mg/mL test substance preparation. The calibration standards injection sequence was repeated following the test substance injections. The HPLC system was operated under standardised isocratic, reverse-phase operating conditions per the guideline.
RESULTS
Under the chromatographic conditions specified, the test substance eluted as three peaks on the ELSD. The corresponding Log Koc for the test substance by UV ranged from unretained (< urea) to 4.43.
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